Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | FASN | P49327 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 3/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6714 | 1.00 | ATM (0.39) | ATMFASNELANEKDM1AKCNH2 | |
| SCHEMBL6395 | 0.85 | ATM (0.39) | ATMFASNELANEKDM1AKCNH2 | |
| SCHEMBL6393 | 0.85 | ATM (0.39) | ATMFASNELANEKDM1AKCNH2 | |
| SCHEMBL6436 | 0.84 | ATM (0.37) | ATMFASNELANEKDM1AF10 | |
| SCHEMBL6438 | 0.84 | ATM (0.37) | ATMFASNELANEKDM1AF10 | |
| SCHEMBL5952 | 0.84 | PTGER4 (0.41) | FASNF10ALDH1A1 | |
| SCHEMBL11909934 | 0.84 | NPC1 (0.41) | F10ALDH1A1 | |
| SCHEMBL11183 | 0.81 | SCD (0.44) | CYP2D6 | |
| SCHEMBL10298 | 0.81 | F10 (0.41) | FASNKDM1AF10ALDH1A1 | |
| SCHEMBL6062 | 0.79 | FASN (0.44) | FASNKDM1AKCNH2PAX8VNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493310-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GlaxoSmithKline LLC (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011056635-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |