Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 5/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.32 |
| ▸ | USP7 | Q93009 | 1/20 | 0.32 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3275068 | 0.83 | IKBKB (0.34) | CHEK2CLK4 | |
| SCHEMBL4029655 | 0.73 | MAPT (0.50) | MAPTLRRK2CHEK2NCOA1NCOA3 | |
| SCHEMBL4029897 | 0.71 | LRRK2 (0.44) | MAPTLRRK2CHEK2NCOA1NCOA3 | |
| SCHEMBL24690187 | 0.69 | LRRK2 (0.42) | MAPTLRRK2CHEK2NCOA1NCOA3 | |
| SCHEMBL30019952 | 0.69 | LRRK2 (0.42) | MAPTLRRK2CHEK2NCOA1NCOA3 | |
| SCHEMBL4026769 | 0.67 | MAPT (0.36) | MAPTLRRK2CHEK2NCOA1NCOA3 | |
| SCHEMBL751010 | 0.66 | MKNK1 (0.42) | CHEK2ALDH1A1 | |
| SCHEMBL4436864 | 0.65 | MKNK1 (0.47) | MAPTCHEK2FYNCYP1A2CYP3A4 | |
| SCHEMBL5468764 | 0.63 | CYP3A4 (0.39) | MAPTCYP3A4ALDH1A1TSHRCLK4 | |
| SCHEMBL22259605 | 0.62 | LRRK2 (0.55) | MAPTLRRK2CYP1A2CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004022525-A1 | AMIDE DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2004-03-18 | — | — | WO | claimed |
| WO-2004022525-A1 | AMIDE DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2004-03-18 | — | — | WO | disclosed |