⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18258290 | 0.79 | — | — | |
| SCHEMBL25119294 | 0.79 | — | — | |
| SCHEMBL1687971 | 0.71 | — | — | |
| SCHEMBL1654819 | 0.69 | — | — | |
| SCHEMBL19019557 | 0.69 | — | — | |
| SCHEMBL23430392 | 0.67 | — | — | |
| SCHEMBL1533841 | 0.65 | PPARA (0.32) | — | |
| SCHEMBL13559270 | 0.61 | — | — | |
| SCHEMBL23809710 | 0.61 | — | — | |
| SCHEMBL1075123 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040261198-A1 | Restructuring and finishing of keratin fibers | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) | 2004-12-30 | — | — | US | claimed |
| US-20170333440-A1 | TRICYCLIC LACTAMS FOR USE IN HSPC-SPARING TREATMENTS FOR RB-POSITIVE ABNORMAL CELLULAR PROLIFERATION | G1 THERAPEUTICS, INC. (US) | 2017-11-23 | — | — | US | disclosed |
| US-9725465-B2 | Biaryl acetamide compounds and methods of use thereof | AMBIT BIOSCIENCES CORPORATION (US) | 2017-08-08 | — | — | US | disclosed |
| US-9717735-B2 | Tricyclic lactams for use in HSPC-sparing treatments for RB-positive abnormal cellular proliferation | G1 THERAPEUTICS, INC. (US) | 2017-08-01 | — | — | US | disclosed |
| US-20150299212-A1 | Tricyclic Lactams for Use in HSPC-Sparing Treatments for RB-Positive Abnormal Cellular Proliferation | G1 THERAPEUTICS, INC. (US) | 2015-10-22 | — | — | US | disclosed |
| US-20150297608-A1 | Tricyclic Lactams for Use as Anti-Neoplastic and Anti-Proliferative Agents | G1 THERAPEUTICS, INC. (US) | 2015-10-22 | — | — | US | disclosed |
| US-20150297607-A1 | Tricyclic Lactams for Use in the Protection of Normal Cells During Chemotherapy | G1 THERAPEUTICS, INC. (US) | 2015-10-22 | — | — | US | disclosed |
| US-8987453-B2 | Azaadamantane derivatives and methods of use | ABBVIE INC. (US) | 2015-03-24 | — | — | US | disclosed |
| US-20150065468-A1 | BIARYL ACETAMIDE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORP (US) | 2015-03-05 | — | — | US | disclosed |
| US-20130096132-A1 | AZAADAMANTANE DERIVATIVES AND METHODS OF USE | ABBVIE INC. (US) | 2013-04-18 | — | — | US | disclosed |
| US-8314119-B2 | Azaadamantane derivatives and methods of use | ABBVIE INC. (US) | 2012-11-20 | — | — | US | disclosed |
| US-20110065133-A1 | O-ring Systems and Methods for Quantification of Multiplex Biomarkers in Multiple Samples | LIU WEIQUN | 2011-03-17 | — | — | US | disclosed |
| US-20080167336-A1 | Alzheimer's disease; central nervous system disorders; aids; Pick's disease; attention deficit disorder; hyperactivity; Down's syndrome, amytropic lateral sclerosis; Huntington's disease; suppression of smoking; drug abruse; brain disorders; analgesics; antiinflammatory agents | ABBOTT LABORATORIES (US) | 2008-07-10 | — | — | US | disclosed |
| US-20040261198-A1 | Restructuring and finishing of keratin fibers | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) | 2004-12-30 | — | — | US | disclosed |