Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 20/20 | 0.72 |
| ▸ | SLC6A2 | P23975 | 19/20 | 0.72 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.70 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL672519 | 1.00 | SLC6A4 (0.72) | SLC6A4SLC6A2SLC6A3CHRM4CYP3A4 | |
| SCHEMBL5887735 | 0.82 | SLC6A2 (0.97) | SLC6A4SLC6A2SLC6A3CHRM4CYP3A4 | |
| SCHEMBL16798485 | 0.82 | SLC6A4 (0.55) | SLC6A4SLC6A2SLC6A3CHRM4CYP3A4 | |
| SCHEMBL15380383 | 0.81 | SLC6A2 (0.69) | SLC6A4SLC6A2SLC6A3CHRM4CYP3A4 | |
| SCHEMBL5888074 | 0.81 | SLC6A2 (0.95) | SLC6A4SLC6A2SLC6A3CHRM4CYP3A4 | |
| SCHEMBL5887817 | 0.81 | SLC6A2 (0.95) | SLC6A4SLC6A2SLC6A3CHRM4CYP3A4 | |
| SCHEMBL5888234 | 0.78 | SLC6A2 (1.00) | SLC6A4SLC6A2SLC6A3CHRM4CYP3A4 | |
| SCHEMBL3065696 | 0.77 | SLC6A4 (0.62) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL3065694 | 0.77 | SLC6A4 (0.62) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| Hydrochloric Acid SCHEMBL5887958 | 0.77 | SLC6A2 (0.98) | SLC6A4SLC6A2SLC6A3CHRM4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10369153-B2 | Pyrrolopyrimidine compounds and uses thereof | HUTCHISON MEDIPHARMA LIMITED (CN) | 2019-08-06 | — | — | US | disclosed |
| US-10111875-B2 | Pyrrolopyrimidine compounds and uses thereof | HUTCHINSON MEDIPHARMA LIMITED (CN) | 2018-10-30 | — | — | US | disclosed |
| EP-2606051-B1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LTD (CN) | 2016-10-05 | — | — | EP | disclosed |
| US-20160228443-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED | 2016-08-11 | — | — | US | disclosed |
| US-9346810-B2 | Pyrrolopyrimidine compounds and uses thereof | HUTCHISON MEDIPHARMA LIMITED (CN) | 2016-05-24 | — | — | US | disclosed |
| CN-103119045-B | Pyrrolopyrimidine compounds and uses thereof | HUTCHISON MEDIPHARMA LTD. (CN) | 2016-02-17 | — | — | CN | disclosed |
| US-20130210831-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2013-08-15 | — | — | US | disclosed |
| CN-103119045-A | Pyrrolopyrimidine compounds and uses thereof | HUTCHISON MEDIPHARMA SHANGHAI CO LTD | 2013-05-22 | — | — | CN | disclosed |
| WO-2012022045-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160228443-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | JAK2, JAK1, JAK3 | SLC6A4 4500/4885SLC6A2 4796/4885SLC6A3 4625/4885 |
| US-10111875-B2 | Pyrrolopyrimidine compounds and uses thereof | JAK2, JAK1, JAK3 | SLC6A4 4500/4885SLC6A2 4796/4885SLC6A3 4625/4885 |
| US-10369153-B2 | Pyrrolopyrimidine compounds and uses thereof | JAK2, JAK1, JAK3 | SLC6A4 4500/4885SLC6A2 4796/4885SLC6A3 4625/4885 |
| US-20130210831-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | JAK2, JAK1, JAK3 | SLC6A4 4500/4885SLC6A2 4796/4885SLC6A3 4625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.