Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 7/20 | 0.53 |
| ▸ | RAB9A | P51151 | 7/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.51 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.51 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2660937 | 0.84 | NPC1 (0.58) | MEN1KMT2AL3MBTL1KDM4ENPC1 | |
| SCHEMBL6671344 | 0.83 | NPC1 (0.54) | MEN1KMT2AL3MBTL1KDM4ENPC1 | |
| SCHEMBL394777 | 0.81 | CFTR (0.65) | MEN1KMT2AL3MBTL1KDM4ENPC1 | |
| SCHEMBL6722139 | 0.81 | RXFP1 (0.54) | MEN1KMT2AL3MBTL1KDM4ENPC1 | |
| SCHEMBL6722035 | 0.79 | HTR2C (0.44) | MEN1KMT2AL3MBTL1KDM4ENPC1 | |
| SCHEMBL6724535 | 0.78 | KDR (0.65) | MEN1KMT2AL3MBTL1KDM4ENPC1 | |
| SCHEMBL6729649 | 0.77 | HTR2C (0.47) | MEN1KMT2AL3MBTL1KDM4ENPC1 | |
| SCHEMBL6726671 | 0.77 | PIM1 (0.43) | MEN1KMT2AL3MBTL1KDM4ENPC1 | |
| SCHEMBL6722076 | 0.76 | MEN1 (0.42) | MEN1KMT2AL3MBTL1KDM4ENPC1 | |
| SCHEMBL6722073 | 0.76 | NPC1 (0.42) | MEN1KMT2AL3MBTL1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673811-B1 | TREATMENT OF ANXIETY, DEPRESSION, SLEEP DISORDER, ATTENTION DEFICIT DISORDER, ALZHEIMER'S DEMENTIA, OR SHORT-TERM MEMORY LOSS | NEUROGEN CORPORATION | 2004-01-06 | — | — | US | claimed |
| US-6673811-B1 | TREATMENT OF ANXIETY, DEPRESSION, SLEEP DISORDER, ATTENTION DEFICIT DISORDER, ALZHEIMER'S DEMENTIA, OR SHORT-TERM MEMORY LOSS | NEUROGEN CORPORATION | 2004-01-06 | — | — | US | disclosed |