Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | GALR3 | O60755 | 1/20 | 0.68 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.68 |
| ▸ | ADK | P55263 | 13/20 | 0.62 |
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.62 |
| ▸ | STAT6 | P42226 | 3/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | DPP4 | P27487 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.54 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6728177 | 0.91 | NPC1 (0.72) | NPC1GALR3S1PR4ALDH1A1MAPT | |
| SCHEMBL13977802 | 0.91 | NPC1 (0.72) | NPC1GALR3S1PR4ALDH1A1MAPT | |
| SCHEMBL17819001 | 0.91 | NPC1 (0.72) | NPC1GALR3S1PR4ALDH1A1MAPT | |
| Sangivamycin SCHEMBL12284269 | 0.86 | NPC1 (0.82) | NPC1GALR3S1PR4ALDH1A1MAPT | |
| Sangivamycin SCHEMBL15107357 | 0.86 | NPC1 (0.82) | NPC1GALR3S1PR4ALDH1A1MAPT | |
| Sangivamycin SCHEMBL14227089 | 0.86 | NPC1 (0.82) | NPC1GALR3S1PR4ALDH1A1MAPT | |
| Sangivamycin SCHEMBL195540 | 0.86 | NPC1 (0.82) | NPC1GALR3S1PR4ALDH1A1MAPT | |
| Sangivamycin SCHEMBL13065171 | 0.86 | NPC1 (0.82) | NPC1GALR3S1PR4ALDH1A1MAPT | |
| Sangivamycin SCHEMBL10262607 | 0.86 | NPC1 (0.82) | NPC1GALR3S1PR4ALDH1A1MAPT | |
| Sangivamycin SCHEMBL2786660 | 0.86 | NPC1 (0.82) | NPC1GALR3S1PR4ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183249-B2 | Inhibitors of AKT/PKB with anti-tumor activity | UNIVERSITY OF SOUTH FLORIDA (US) | 2012-05-22 | — | — | US | disclosed |