Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 19/20 | 0.73 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6735326 | 0.95 | GRM2 (0.66) | GRM2NPC1RAB9A | |
| SCHEMBL6727574 | 0.91 | GRM2 (0.59) | GRM2NPC1RAB9A | |
| SCHEMBL6727654 | 0.88 | GRM2 (0.65) | GRM2 | |
| SCHEMBL6739549 | 0.86 | GRM2 (0.53) | GRM2NPC1RAB9A | |
| SCHEMBL6732349 | 0.85 | GRM2 (1.00) | GRM2 | |
| SCHEMBL6835954 | 0.84 | GRM2 (0.81) | GRM2 | |
| SCHEMBL6735675 | 0.84 | GRM2 (0.89) | GRM2 | |
| SCHEMBL6733731 | 0.84 | GRM2 (0.84) | GRM2 | |
| SCHEMBL6733846 | 0.83 | GRM2 (0.80) | GRM2 | |
| SCHEMBL6738268 | 0.83 | GRM2 (0.83) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6800651-B2 | Potentiators of glutamate receptors | ELI LILLY AND COMPANY | 2004-10-05 | — | — | US | claimed |
| US-20040006114-A1 | Potentiators of glutamate receptors | ELI LILLY AND COMPANY | 2004-01-08 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006114-A1 | Potentiators of glutamate receptors | GRM1, GRIN1, GRM2 | GRM2 3/4885NPC1 1454/4885RAB9A 2810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.