Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.69 |
| ▸ | KDM5A | P29375 | 2/20 | 0.69 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.47 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.47 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.47 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | F3 | P13726 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1472608 | 0.87 | KDM5A (0.56) | KDM4CKDM5ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL21042568 | 0.85 | KDM5A (0.54) | KDM4CKDM5ACSNK2A2CSNK2BCSNK2A1 | |
| Potassium Ion SCHEMBL1763260 | 0.82 | KDM5A (0.51) | KDM4CKDM5ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL12215399 | 0.82 | KDM5A (0.51) | KDM4CKDM5ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL16157363 | 0.81 | KDM5A (1.00) | KDM4CKDM5ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL1763380 | 0.79 | KDM5A (0.48) | KDM4CKDM5ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL29956210 | 0.77 | KDM5A (0.65) | KDM4CKDM5ATET2TET1SMN1; SMN2 | |
| SCHEMBL21509475 | 0.76 | KDM4C (0.55) | KDM4CKDM5ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL2080225 | 0.76 | KDM5A (0.47) | KDM4CKDM5ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL17818839 | 0.75 | CSNK2A1 (0.52) | KDM4CKDM5ACSNK2A2CSNK2BCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673811-B1 | TREATMENT OF ANXIETY, DEPRESSION, SLEEP DISORDER, ATTENTION DEFICIT DISORDER, ALZHEIMER'S DEMENTIA, OR SHORT-TERM MEMORY LOSS | NEUROGEN CORPORATION | 2004-01-06 | — | — | US | claimed |
| US-6673811-B1 | TREATMENT OF ANXIETY, DEPRESSION, SLEEP DISORDER, ATTENTION DEFICIT DISORDER, ALZHEIMER'S DEMENTIA, OR SHORT-TERM MEMORY LOSS | NEUROGEN CORPORATION | 2004-01-06 | — | — | US | disclosed |