Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.59 |
| ▸ | CA4 | P22748 | 4/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CPT2 | P23786 | 1/20 | 0.37 |
| ▸ | CPT1A | P50416 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6733940 | 0.93 | SLC22A16 (0.59) | SLC22A16CA4CA2SLC22A6CTSL | |
| SCHEMBL10423091 | 0.93 | CA4 (0.60) | SLC22A16CA4CA2SLC22A6CTSL | |
| Potassium Ion SCHEMBL28596754 | 0.93 | SLC22A16 (0.59) | SLC22A16CA4CA2SLC22A6CTSL | |
| SCHEMBL7465722 | 0.79 | — | — | |
| Lithium Ion SCHEMBL28940539 | 0.79 | — | — | |
| SCHEMBL4427757 | 0.79 | — | — | |
| SCHEMBL31500043 | 0.77 | — | — | |
| SCHEMBL21328525 | 0.77 | — | — | |
| SCHEMBL21546042 | 0.77 | — | — | |
| SCHEMBL29635923 | 0.77 | SLC22A16 (0.56) | SLC22A16CA4CA2CTSLCPT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6686133-B2 | CONTAINING LIGHT-INSENSITIVE SILVER SALTS OF ORGANIC CARBOXYLIC ACIDS WITH ONE OR MORE CARBOXYLIC ACID AND A BINDER, EXCLUSIVE OF SILVER SUCCINATE SIMILAR COMPOUNDS | AGFA-GEVAERT (BE) | 2004-02-03 | — | — | US | disclosed |