Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 18/20 | 0.60 |
| ▸ | SRC | P12931 | 2/20 | 0.60 |
| ▸ | IKBKB | O14920 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | LYN | P07948 | 1/20 | 0.60 |
| ▸ | BRAF | P15056 | 1/20 | 0.60 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.60 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.60 |
| ▸ | IGF1R | P08069 | 4/20 | 0.57 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3221719 | 0.94 | MAP2K1 (0.61) | MAP2K1SRCIKBKBEGFRLYN | |
| SCHEMBL3228928 | 0.92 | MAP2K1 (0.70) | MAP2K1SRCIKBKBEGFRLYN | |
| SCHEMBL3219604 | 0.92 | MAP2K1 (0.71) | MAP2K1SRCIKBKBEGFRLYN | |
| SCHEMBL3227776 | 0.91 | MAP2K1 (0.62) | MAP2K1SRCIKBKBEGFRLYN | |
| SCHEMBL3228827 | 0.91 | IGF1R (0.59) | MAP2K1SRCIKBKBEGFRLYN | |
| SCHEMBL3224280 | 0.91 | MAP2K1 (0.58) | MAP2K1SRCIKBKBEGFRLYN | |
| SCHEMBL3231921 | 0.90 | MAP2K1 (0.64) | MAP2K1SRCIKBKBEGFRLYN | |
| SCHEMBL3224442 | 0.90 | MAP2K1 (0.70) | MAP2K1SRCIKBKBEGFRLYN | |
| SCHEMBL3216370 | 0.89 | MAP2K1 (0.63) | MAP2K1SRCIKBKBEGFRLYN | |
| SCHEMBL3230646 | 0.87 | MAP2K1 (0.73) | MAP2K1SRCIKBKBEGFRLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689772-B1 | ANTINEOPLASTIC AGENTS; OSTEOPOROSIS; POLYCYSTIC KIDNEY DISEASE; ANTIVIRAL AGENTS | WYETH | 2004-02-10 | — | — | US | disclosed |