Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | PLK1 | P53350 | 1/20 | 0.58 |
| ▸ | RAF1 | P04049 | 2/20 | 0.56 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.56 |
| ▸ | JAK3 | P52333 | 3/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | FLT3 | P36888 | 3/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.51 |
| ▸ | CDK1 | P06493 | 2/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6742302 | 1.00 | PLK4 (0.58) | PLK4PLK1RAF1PIK3C3JAK3 | |
| SCHEMBL14521195 | 0.88 | FLT3 (0.62) | RAF1PIK3C3JAK3JAK2FLT3 | |
| SCHEMBL14521196 | 0.87 | NPC1 (0.58) | RAF1PIK3C3JAK3JAK2FLT3 | |
| SCHEMBL14521187 | 0.87 | JAK3 (0.53) | RAF1PIK3C3JAK3JAK2FLT3 | |
| SCHEMBL14521201 | 0.85 | JAK3 (0.52) | RAF1PIK3C3JAK3JAK2FLT3 | |
| SCHEMBL14521177 | 0.81 | CHEK1 (0.49) | RAF1PIK3C3JAK3JAK2FLT3 | |
| SCHEMBL14521189 | 0.81 | JAK3 (0.48) | RAF1PIK3C3JAK3JAK2FLT3 | |
| SCHEMBL14521184 | 0.81 | JAK3 (0.55) | RAF1PIK3C3JAK3JAK2FLT3 | |
| SCHEMBL14521194 | 0.81 | JAK3 (0.52) | RAF1PIK3C3JAK3JAK2FLT3 | |
| SCHEMBL14521200 | 0.80 | JAK3 (0.57) | RAF1PIK3C3JAK3JAK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |