Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 19/20 | 0.57 |
| ▸ | BRD2 | P25440 | 3/20 | 0.57 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.57 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.54 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.50 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16196746 | 0.89 | BRD4 (0.67) | BRD4BRD2CREBBPNR3C1PGR | |
| SCHEMBL16348060 | 0.82 | BRD4 (0.55) | BRD4BRD2CREBBPNR3C1PGR | |
| SCHEMBL18189604 | 0.76 | GRIA1 (0.57) | BRD4BRD2CREBBPPGR | |
| SCHEMBL15981288 | 0.75 | BRD4 (0.59) | BRD4BRD2CREBBPNR3C1PGR | |
| SCHEMBL13529011 | 0.75 | CRBN (0.61) | BRD4CREBBPPGR | |
| SCHEMBL24287105 | 0.73 | BRD4 (0.53) | BRD4BRD2CREBBPNR3C1PGR | |
| SCHEMBL4424584 | 0.72 | BRD4 (0.59) | BRD4BRD2CREBBPNR3C1PGR | |
| SCHEMBL16197533 | 0.72 | BRD4 (0.66) | BRD4BRD2BRD3BRDT | |
| SCHEMBL28543984 | 0.71 | CRBN (0.55) | BRD4CREBBPPGR | |
| SCHEMBL16108386 | 0.71 | BRD4 (0.55) | BRD4BRD2CREBBPNR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |