⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL111398 | 1.00 | — | — | |
| SCHEMBL111397 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL1338854 | 0.98 | PTGS1 (0.46) | — | |
| Hydrochloric Acid SCHEMBL28868945 | 0.98 | PTGS1 (0.46) | — | |
| Hydrochloric Acid SCHEMBL28868944 | 0.98 | PTGS1 (0.46) | — | |
| Hydrochloric Acid SCHEMBL1338852 | 0.98 | PTGS1 (0.46) | — | |
| Hydrochloric Acid SCHEMBL123379 | 0.98 | PTGS1 (0.46) | — | |
| SCHEMBL22830533 | 0.98 | PTGS1 (0.46) | — | |
| SCHEMBL22830532 | 0.98 | PTGS1 (0.46) | — | |
| Hydrochloric Acid SCHEMBL1246786 | 0.98 | PTGS1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250215464-A1 | ENGINEERED ENZYME FOR PREPARING A HYDROXYLATED INDANONE INTERMEDIATE USEFUL IN THE SYNTHESIS OF BELZUTIFAN | MERCK SHARP & DOHME LLC (US) | 2025-07-03 | — | — | US | claimed |
| EP-4551592-A1 | ENGINEERED ENZYME FOR PREPARING A HYDROXYLATED INDANONE INTERMEDIATE USEFUL IN THE SYNTHESIS OF BELZUTIFAN | Merck Sharp & Dohme LLC (US) | 2025-05-14 | — | — | EP | claimed |
| CN-119546622-A | Engineering enzymes for preparing hydroxylated indanone intermediates useful for synthesis of bezotevans | 默沙东有限责任公司 | 2025-02-28 | — | — | CN | claimed |
| US-20250009706-A1 | COMPOSITIONS AND METHODS FOR TREATING OPIOID DEPENDENCE AND WITHDRAWAL | CASE WESTERN RESERVE UNIVERSITY | 2025-01-09 | — | — | US | claimed |
| EP-4373484-A1 | COMPOSITIONS AND METHODS FOR TREATING OPIOID DEPENDENCE AND WITHDRAWAL | CASE WESTERN RESERVE UNIVERSITY (US) | 2024-05-29 | — | — | EP | claimed |
| WO-2024010783-A1 | ENGINEERED ENZYME FOR PREPARING A HYDROXYLATED INDANONE INTERMEDIATE USEFUL IN THE SYNTHESIS OF BELZUTIFAN | MERCK SHARP & DOHME LLC (US) | 2024-01-11 | — | — | WO | claimed |
| WO-2023003810-A1 | COMPOSITIONS AND METHODS FOR TREATING OPIOID DEPENDENCE AND WITHDRAWAL | CASE WESTERN RESERVE UNIVERSITY (US) | 2023-01-26 | — | — | WO | claimed |
| US-20210145785-A1 | COMPOSITIONS AND METHODS FOR STIMULATING VENTILATORY AND/OR RESPIRATORY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-05-20 | — | — | US | claimed |
| US-10881633-B2 | Compositions and methods for stimulating ventilatory and/or respiratory drive | CASE WESTERN RESERVE UNIVERSITY (US) | 2021-01-05 | — | — | US | claimed |
| US-20250262181-A1 | COMPOSITIONS AND METHODS FOR STIMULATING VENTILATORY AND/OR RESPIRATORY | UNIV CASE WESTERN RESERVE (US) | 2025-08-21 | — | — | US | disclosed |
| US-20250215464-A1 | ENGINEERED ENZYME FOR PREPARING A HYDROXYLATED INDANONE INTERMEDIATE USEFUL IN THE SYNTHESIS OF BELZUTIFAN | MERCK SHARP & DOHME LLC (US) | 2025-07-03 | — | — | US | disclosed |
| WO-2025123013-A1 | COMPOSITIONS FOR TREATING ADDICTION, DEPENDENCE, WITHDRAWAL, AND/OR OPIOID INDUCED HYPERALGESIA | CASE WESTERN RESERVE UNIVERSITY (US) | 2025-06-12 | — | — | WO | disclosed |
| EP-4551592-A1 | ENGINEERED ENZYME FOR PREPARING A HYDROXYLATED INDANONE INTERMEDIATE USEFUL IN THE SYNTHESIS OF BELZUTIFAN | Merck Sharp & Dohme LLC (US) | 2025-05-14 | — | — | EP | disclosed |
| CN-119546622-A | Engineering enzymes for preparing hydroxylated indanone intermediates useful for synthesis of bezotevans | 默沙东有限责任公司 | 2025-02-28 | — | — | CN | disclosed |
| US-7829063-B2 | Development of molecular imaging probes for carbonic anhydrase-IX using click chemistry | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2010-11-09 | — | — | US | disclosed |
| US-6685617-B1 | 4-(((-1-CARBOXY-2-(4-((2,6-DICHLOROBENZOYL)AMINE)PHENYL)ETHYL) AMINO)CARBONYL)-3-OXO-3-THIAZOLIDINEBUTANOIC ACID, USED AS ANTAGONISTS FOR CELLULAR ADHESION MOLECULES, AND ADMINISTERED AS ANTIINFLAMMATORY AGENTS | PHARMACIA & UPJOHN COMPANY | 2004-02-03 | — | — | US | disclosed |
| EP-1089989-A1 | INHIBITORS OF ALPHA4BETA1 MEDIATED CELL ADHESION | PHARMACIA & UPJOHN COMPANY (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067230-A1 | INHIBITORS OF α4β1 MEDIATED CELL ADHESION | PHARMACIA & UPJOHN COMPANY (US) | 1999-12-29 | — | — | WO | disclosed |
| US-4357331-A | 7αMethoxycephalosporin derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 1982-11-02 | — | — | US | disclosed |
| US-4325951-A | 1-Oxadethiacephalosporin derivatives and antibacterial use thereof | MEIJI SEIKA KAISHA, LTD. (JP) | 1982-04-20 | — | — | US | disclosed |