Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 6/20 | 0.58 |
| ▸ | RPS6KB2 | Q9UBS0 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | PRKDC | P78527 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TNFRSF1A | P19438 | 5/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5560733 | 0.83 | TNFRSF1A (0.57) | ERN1RPS6KB2KDM4EALDH1A1TSHR | |
| SCHEMBL31231819 | 0.83 | ERN1 (0.54) | ERN1KDM4EALDH1A1TSHRTDP1 | |
| SCHEMBL6040741 | 0.81 | ERN1 (0.61) | ERN1RPS6KB2KDM4EALDH1A1TSHR | |
| SCHEMBL6040729 | 0.80 | MAOB (0.51) | ERN1KDM4EALDH1A1TDP1CYP3A4 | |
| SCHEMBL3680495 | 0.80 | ERN1 (0.52) | ERN1KDM4EALDH1A1TDP1CYP3A4 | |
| SCHEMBL5565309 | 0.80 | ERN1 (0.60) | ERN1RPS6KB2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL2780877 | 0.79 | RPS6KB2 (0.56) | ERN1RPS6KB2KDM4EALDH1A1TSHR | |
| SCHEMBL5937486 | 0.77 | ERN1 (0.59) | ERN1RPS6KB2ALDH1A1TSHRTDP1 | |
| SCHEMBL5960661 | 0.77 | ERN1 (0.68) | ERN1TNFRSF1A | |
| SCHEMBL6040725 | 0.76 | ERN1 (0.50) | ERN1RPS6KB2KDM4EALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |