Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.73 |
| ▸ | RET | P07949 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.44 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.44 |
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
| ▸ | FLT1 | P17948 | 2/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.44 |
| ▸ | FLT4 | P35916 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6744832 | 1.00 | TDP1 (0.73) | TDP1RETMAPTGAAALDH1A1 | |
| SCHEMBL6742976 | 0.87 | TDP1 (0.54) | TDP1RETMAPTGAAALDH1A1 | |
| SCHEMBL6742981 | 0.87 | TDP1 (0.54) | TDP1RETMAPTGAAALDH1A1 | |
| SCHEMBL725960 | 0.85 | TDP1 (1.00) | TDP1MAPTGAAALDH1A1TTR | |
| SCHEMBL29670839 | 0.85 | TDP1 (1.00) | TDP1MAPTGAAALDH1A1TTR | |
| SCHEMBL2825850 | 0.75 | TDP1 (0.75) | TDP1MAPTGAAALDH1A1TTR | |
| SCHEMBL13207340 | 0.75 | TDP1 (0.75) | TDP1MAPTGAAALDH1A1TTR | |
| SCHEMBL2825852 | 0.75 | TDP1 (0.75) | TDP1MAPTGAAALDH1A1TTR | |
| SCHEMBL6406357 | 0.75 | TDP1 (0.75) | TDP1MAPTGAAALDH1A1TTR | |
| SCHEMBL5469189 | 0.75 | KDR (0.48) | TDP1RETMAPTALDH1A1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |