Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.72 |
| ▸ | MITF | O75030 | 5/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.72 |
| ▸ | HTT | P42858 | 2/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | F2R | P25116 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | XBP1 | P17861 | 1/20 | 0.61 |
| ▸ | OXTR | P30559 | 1/20 | 0.61 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6748462 | 0.92 | MAPT (0.82) | MAPTKMT2AMITFKDM4EHTT | |
| Bromide SCHEMBL6752864 | 0.90 | MAPT (0.72) | MAPTKMT2AMITFKDM4EHTT | |
| Bromide SCHEMBL6746416 | 0.88 | MAPT (0.71) | MAPTKMT2AMITFKDM4EHTT | |
| SCHEMBL5460666 | 0.87 | MAPT (0.69) | MAPTKMT2AMITFKDM4EHTT | |
| SCHEMBL14470550 | 0.87 | MAPT (0.88) | MAPTKMT2AMITFKDM4EHTT | |
| Bromide SCHEMBL6750274 | 0.85 | MAPT (0.67) | MAPTKMT2AMITFKDM4EHTT | |
| Bromide SCHEMBL6752895 | 0.84 | F2R (0.70) | MAPTKMT2AMITFKDM4EHTT | |
| Bromide SCHEMBL6750417 | 0.83 | MAPT (0.61) | MAPTKMT2AMITFKDM4EHTT | |
| Bromide SCHEMBL6751209 | 0.83 | KMT2A (0.64) | MAPTKMT2AMITFKDM4EHTT | |
| Bromide SCHEMBL6752701 | 0.83 | NPSR1 (0.58) | MAPTKMT2AMITFKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040242627-A1 | 2-Iminoimidazole derivatives (1) | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2004-12-02 | — | — | US | disclosed |
| US-20040191629-A1 | Anode of sulfur; cathode of lithium silicide; molten metal compound as electrolytes | SANYO ELECTRIC CO., LTD. | 2004-09-30 | — | — | US | disclosed |
| EP-1394152-A1 | 2-IMINOIMIDAZOLE DERIVATIVES (1) | Eisai Co., Ltd. (JP) | 2004-03-03 | — | — | EP | disclosed |
| US-20020151714-A1 | PROCESS FOR PREPARING 1,4-DISUBSTITUTED PIPERIDINE COMPOUNDS | CILAG AG (CH) | 2002-10-17 | — | — | US | disclosed |
| US-6322722-B1 | BUTYLENE OXIDE DERIVATIVE AND HYDROCARBON BLOWING AGENT; PRODUCES LOW DENSITY, WITHOUT HIGHER CONCENTRATION OF WATER | THE DOW CHEMICAL COMPANY | 2001-11-27 | — | — | US | disclosed |
| US-5942530-A | Method for treating pain | ELI LILLY AND COMPANY (US) | 1999-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242627-A1 | 2-Iminoimidazole derivatives (1) | H1-2, H1-0, H1-3 | MAPT 4077/4885KMT2A 340/4885MITF 3456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.