Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 11/20 | 0.53 |
| ▸ | IGF1R | P08069 | 3/20 | 0.51 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.51 |
| ▸ | MAP3K8 | P41279 | 6/20 | 0.48 |
| ▸ | SRC | P12931 | 4/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | PRKCG | P05129 | 1/20 | 0.44 |
| ▸ | PRKCB | P05771 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | PRKCH | P24723 | 1/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3233282 | 0.88 | MAP2K1 (0.53) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL6748427 | 0.88 | MAP2K1 (0.53) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL3233980 | 0.86 | SRC (0.53) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL3228173 | 0.83 | MAP2K1 (0.55) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL3215737 | 0.82 | SRC (0.54) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL3228144 | 0.82 | MAP2K1 (0.53) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL3228240 | 0.81 | SRC (0.60) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL3223664 | 0.81 | MAP2K1 (0.53) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL5253249 | 0.81 | SRC (0.64) | MAP2K1SRCEGFRPRKCQ | |
| SCHEMBL3229400 | 0.80 | SRC (0.56) | MAP2K1IGF1RSRCEGFRPRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040176602-A1 | 3-Cyanoquinolines,3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors | WYETH | 2004-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176602-A1 | 3-Cyanoquinolines,3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors | PKD1, PKD2, CSNK1A1 | MAP2K1 568/4885IGF1R 1028/4885MAPK3 44/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.