Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.77 |
| ▸ | CDK1 | P06493 | 1/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.74 |
| ▸ | MEN1 | O00255 | 4/20 | 0.74 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.68 |
| ▸ | AURKA | O14965 | 7/20 | 0.67 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | UBE2N | P61088 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | RAD52 | P43351 | 3/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6748506 | 0.91 | CHEK1 (0.82) | CHEK1CDK1KMT2AMEN1TNK2 | |
| SCHEMBL13632594 | 0.90 | AURKA (0.81) | CHEK1KMT2AMEN1TNK2AURKA | |
| SCHEMBL4531850 | 0.90 | KMT2A (0.92) | CHEK1CDK1KMT2AMEN1TNK2 | |
| SCHEMBL4520017 | 0.88 | KMT2A (0.85) | CHEK1CDK1KMT2AMEN1TNK2 | |
| SCHEMBL4519943 | 0.88 | AURKA (0.84) | CHEK1CDK1KMT2AMEN1TNK2 | |
| SCHEMBL6749207 | 0.88 | AURKA (0.84) | CHEK1CDK1KMT2AMEN1TNK2 | |
| SCHEMBL6749226 | 0.88 | AURKA (0.84) | CHEK1CDK1KMT2AMEN1TNK2 | |
| SCHEMBL6748499 | 0.87 | CHEK1 (0.67) | CHEK1CDK1KMT2AMEN1TNK2 | |
| SCHEMBL12355053 | 0.87 | CHEK1 (1.00) | CHEK1CDK1KMT2AMEN1TNK2 | |
| SCHEMBL14923114 | 0.86 | KDM4E (0.71) | CHEK1CDK1KMT2AMEN1TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183246-B2 | Acyclically substituted furopyrimidine derivatives and use thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-05-22 | — | — | US | disclosed |
| US-20090318475-A1 | Novel, Acyclically Substituted Furopyrimidine Derivatives and Use Thereof | BAYER HEALTHCARE AG (DE) | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318475-A1 | Novel, Acyclically Substituted Furopyrimidine Derivatives and Use Thereof | DPYD, PNPO, TPMT | CHEK1 969/4885CDK1 1366/4885KMT2A 3401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.