SCHEMBL6750871

SCHEMBL6750871

O=C(O)C(Cc1ccc(CCCN2c3cccnc3Cc3ncccc32)cc1)OCc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PPARG P37231 17/20 0.47
PPARA Q07869 15/20 0.45
PPARD Q03181 2/20 0.41
SRR Q9GZT4 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6754475 0.90 PPARG (0.59) PPARGPPARAPPARD
SCHEMBL6748813 0.89 PPARG (0.57) PPARGPPARAPPARD
SCHEMBL6752416 0.87 PPARG (0.51) PPARGPPARAPPARD
SCHEMBL6750850 0.87 PPARG (0.59) PPARGPPARAPPARD
SCHEMBL6754564 0.87 PPARG (0.45) PPARGPPARAPPARDSRR
SCHEMBL6858695 0.85 PPARG (0.48) PPARGPPARAPPARD
SCHEMBL7527420 0.81 PPARG (0.59) PPARGPPARAPPARDSRR
SCHEMBL7531466 0.81 PPARG (0.59) PPARGPPARAPPARDSRR
SCHEMBL6752859 0.80 PPARG (0.46) PPARGPPARAPPARDSRR
SCHEMBL6753160 0.80 PPARG (0.71) PPARGPPARAPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020065268-A1 New compounds, their preparation and use JEPPESEN LONE (DK) 2002-05-30 US claimed
US-20020065267-A1 Compounds, their preparation and use JEPPESEN LONE (DK) 2002-05-30 US claimed
US-20020061880-A1 New compounds, their preparation and use JEPPESEN LONE (DK) 2002-05-23 US claimed
US-20020061876-A1 Compounds, their preparation and use JEPPESEN LONE (DK) 2002-05-23 US claimed
US-20020055502-A1 New compounds, their preparation and use JEPPESEN LONE (DK) 2002-05-09 US claimed
US-6703401-B2 USEFUL IN THE TREATMENT AND/OR PREVENTION OF CONDITIONS MEDIATED BY CLEAR RECEPTORS, IN PARTICULAR THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR). NOVO NORDISK A/S (DK) 2004-03-09 US disclosed
US-20020065268-A1 New compounds, their preparation and use JEPPESEN LONE (DK) 2002-05-30 US disclosed
US-20020065267-A1 Compounds, their preparation and use JEPPESEN LONE (DK) 2002-05-30 US disclosed
US-20020061880-A1 New compounds, their preparation and use JEPPESEN LONE (DK) 2002-05-23 US disclosed
US-20020061876-A1 Compounds, their preparation and use JEPPESEN LONE (DK) 2002-05-23 US disclosed
US-20020055502-A1 New compounds, their preparation and use JEPPESEN LONE (DK) 2002-05-09 US disclosed
US-6365586-B1 REDUCE BLOOD GLUCOSE AND TRIGLYCERIDE LEVELS AND ARE USEFUL FOR THERAPY OF AILMENTS AND DISORDERS SUCH AS DIABETES AND OBESITY NOVO NORDISK A/S (DK) 2002-04-02 US disclosed
EP-1123297-A1 NEW COMPOUNDS, THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 2001-08-16 EP disclosed
WO-2000023451-A1 NEW COMPOUNDS, THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 2000-04-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020061880-A1 New compounds, their preparation and use PPARG, PPARD, PPARA PPARG 1/4885PPARA 3/4885PPARD 2/4885
US-20020065267-A1 Compounds, their preparation and use PPARG, PPARA, PPARD PPARG 1/4885PPARA 2/4885PPARD 3/4885
US-20020061876-A1 Compounds, their preparation and use PPARG, PPARA, PPARD PPARG 1/4885PPARA 2/4885PPARD 3/4885
US-20020055502-A1 New compounds, their preparation and use PPARG, PPARD, PPARA PPARG 1/4885PPARA 3/4885PPARD 2/4885
US-20020065268-A1 New compounds, their preparation and use PPARG, PPARD, PPARA PPARG 1/4885PPARA 3/4885PPARD 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.