Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.56 |
| ▸ | BACE1 | P56817 | 1/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 5/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL675143 | 1.00 | PTPN1 (0.56) | PTPN1BACE1PPARGPPARAAPP | |
| SCHEMBL10046173 | 0.91 | PPARG (0.52) | PTPN1BACE1PPARGPPARAAPP | |
| SCHEMBL17938148 | 0.91 | PPARG (0.52) | PTPN1BACE1PPARGPPARAAPP | |
| SCHEMBL672093 | 0.83 | LSS (0.48) | — | |
| SCHEMBL672094 | 0.83 | LSS (0.48) | — | |
| SCHEMBL11856404 | 0.80 | KMT2A (0.48) | PTPN1BACE1PPARGPPARAAPP | |
| SCHEMBL11856399 | 0.80 | KMT2A (0.48) | PTPN1BACE1PPARGPPARAAPP | |
| SCHEMBL29405191 | 0.76 | BACE1 (0.59) | PTPN1BACE1PPARGPPARAAPP | |
| SCHEMBL10046361 | 0.75 | PPARG (0.38) | PTPN1BACE1PPARGPPARAAPP | |
| SCHEMBL10046197 | 0.74 | LSS (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2605767-B1 | SHIP1 MODULATORS AND RELATED METHODS | UNIV BRITISH COLUMBIA (CA) | 2016-07-27 | — | — | EP | disclosed |
| EP-2605767-A1 | SHIP1 MODULATORS AND RELATED METHODS | The University Of British Columbia (CA) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012024682-A1 | SHIP1 MODULATORS AND RELATED METHODS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2012-02-23 | — | — | WO | disclosed |