Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 14/20 | 0.71 |
| ▸ | HTR1B | P28222 | 9/20 | 0.71 |
| ▸ | HTR2A | P28223 | 7/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.71 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.71 |
| ▸ | MEN1 | O00255 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.71 |
| ▸ | TP53 | P04637 | 2/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.71 |
| ▸ | HTR1A | P08908 | 2/20 | 0.71 |
| ▸ | HTR2C | P28335 | 2/20 | 0.71 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.71 |
| ▸ | HTR3B | O95264 | 1/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gr-127935 SCHEMBL29462286 | 0.83 | HTR1D (1.00) | HTR1DHTR1BHTR2AMAPTSLC6A4 | |
| Gr-127935 SCHEMBL7795263 | 0.83 | HTR1D (1.00) | HTR1DHTR1BHTR2AMAPTSLC6A4 | |
| Gr-127935 SCHEMBL29657121 | 0.82 | MEN1 (1.00) | HTR1DHTR1BHTR2AMAPTSLC6A4 | |
| Gr-127935 SCHEMBL6017123 | 0.82 | MEN1 (1.00) | HTR1DHTR1BHTR2AMAPTSLC6A4 | |
| SCHEMBL9567470 | 0.82 | HTR1D (0.53) | HTR1DHTR1BHTR2AMAPTSLC6A4 | |
| SCHEMBL7801411 | 0.80 | HTR1D (1.00) | HTR1DHTR1BHTR2AMAPTSLC6A4 | |
| SCHEMBL7803385 | 0.79 | HTR1D (0.69) | HTR1DHTR1BHTR2AMAPTSLC6A4 | |
| SCHEMBL7801017 | 0.79 | HTR1D (0.83) | HTR1DHTR1BHTR2AMAPTSLC6A4 | |
| SCHEMBL7801056 | 0.79 | HTR1D (0.83) | HTR1DHTR1BHTR2AMAPTSLC6A4 | |
| SCHEMBL7795147 | 0.78 | HTR1D (0.91) | HTR1DHTR1BHTR2AMAPTSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170246150-A1 | Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation | OMEROS CORPORATION | 2017-08-31 | — | — | US | disclosed |
| US-20170182007-A1 | Arthroscopic Irrigation Solution and Method for Peripheral Vasoconstriction and Inhibition of Pain and Inflammation | OMEROS CORPORATION | 2017-06-29 | — | — | US | disclosed |
| US-20160184272-A1 | Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation | OMEROS CORPORATION | 2016-06-30 | — | — | US | disclosed |
| US-20160120846-A1 | Arthroscopic Irrigation Solution and Method for Peripheral Vasoconstriction and Inhibition of Pain and Inflammation | OMEROS CORPORATION | 2016-05-05 | — | — | US | disclosed |
| US-20160067219-A1 | Arthroscopic Irrigation Solution and Method for Peripheral Vasoconstriction and Inhibition of Pain and Inflammation | OMEROS CORPORATION | 2016-03-10 | — | — | US | disclosed |
| US-9254271-B2 | Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation | OMEROS CORPORATION (US) | 2016-02-09 | — | — | US | disclosed |
| US-20130324475-A1 | Arthroscopic Irrigation Solution and Method for Peripheral Vasoconstriction and Inhibition of Pain and Inflammation | OMEROS CORPORATION (US) | 2013-12-05 | — | — | US | disclosed |
| US-8450309-B2 | Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation | OMEROS CORPORATION (US) | 2013-05-28 | — | — | US | disclosed |
| EP-2301562-B1 | Irrigation solution and method for inhibition of pain, inflammation and spasm | OMEROS CORP (US) | 2013-04-17 | — | — | EP | disclosed |
| EP-1609477-B1 | Irrigation solution and use thereof for the perioperative inhibition of pain/inflammation and/or spasm at a vascular structure | OMEROS CORP (US) | 2011-11-09 | — | — | EP | disclosed |
| US-20030087962-A1 | Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation | OMEROS CORPORATION | 2003-05-08 | — | — | US | disclosed |
| US-6492332-B1 | Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation | OMEROS CORPORATION | 2002-12-10 | — | — | US | disclosed |
| US-6420432-B2 | DELIVERING ANALGESICS, ANTIINFLAMMATORY AGENTS, AND OTHER ENZYME AND RECEPTOR INHIBITORS LOCALLY TO A WOUND; REDUCED SIDE EFFECTS COMPARED TO SYSTEMIC DELIVERY | OMEROS CORPORATION | 2002-07-16 | — | — | US | disclosed |
| US-20020028798-A1 | Irrigation solution and method for inhibition of pain and inflammation | OMEROS MEDICAL SYSTEMS | 2002-03-07 | — | — | US | disclosed |
| US-20010044616-A1 | Surgical irrigation solution and method for inhibition of pain and inflammation | OMEROS MEDICAL SYSTEMS, INC. | 2001-11-22 | — | — | US | disclosed |
| US-6261279-B1 | Surgical irrigation solution and method for inhibition of pain and inflammation | OMEROS MEDICAL SYSTEMS, INC. | 2001-07-17 | — | — | US | disclosed |
| US-6254585-B1 | Surgical irrigation solution and method for inhibition of pain and inflammation | OMEROS MEDICAL SYSTEMS, INC. | 2001-07-03 | — | — | US | disclosed |
| US-6242447-B1 | AVOIDING UNDESIRABLE SIDE EFFECTS ASSOCIATED WITH ORAL, INTRAMUSCULAR, SUBCUTANEOUS OR INTRAVENOUS APPLICATION OF LARGER DOSES OF THE AGENTS. | OMEROS MEDICAL SYSTEMS, INC. | 2001-06-05 | — | — | US | disclosed |
| US-6210394-B1 | Surgical irrigation solution and method for inhibition of pain and inflammation | OMEROS MEDICAL SYSTEMS, INC. | 2001-04-03 | — | — | US | disclosed |
| US-6056715-A | Surgical irrigation solution and method for inhibition of pain and inflammation | OMEROS MEDICAL SYSTEMS, INC. (US) | 2000-05-02 | — | — | US | disclosed |