SCHEMBL6757495

SCHEMBL6757495

CN(C)C(=O)N1C[C@H]2C[C@@H](O)C[C@H]2C1

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 2/20 0.40
DPP8 Q6V1X1 2/20 0.40
DPP9 Q86TI2 2/20 0.40
MAPT P10636 3/20 0.36
KMT2A Q03164 2/20 0.36
MEN1 O00255 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
HSD17B10 Q99714 1/20 0.35
GAA P10253 1/20 0.33
CHRNB2 P17787 1/20 0.32
CHRNB4 P30926 1/20 0.32
CHRNA3 P32297 1/20 0.32
CHRNA4 P43681 1/20 0.32
ALDH1A1 P00352 1/20 0.32
NR1H2 P55055 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2744311 1.00 DPP4 (0.40) DPP4DPP8DPP9MAPTKMT2A
SCHEMBL13070050 0.83 DPP4 (0.40) DPP4DPP8DPP9MAPTKMT2A
SCHEMBL13070046 0.83 DPP4 (0.40) DPP4DPP8DPP9MAPTKMT2A
SCHEMBL3314638 0.82 MAPT (0.41) DPP4DPP8DPP9MAPTKMT2A
SCHEMBL6757503 0.82 DPP4 (0.39) DPP4DPP8DPP9MAPTKMT2A
SCHEMBL3314634 0.78 MAPT (0.41) DPP4DPP8DPP9MAPTKMT2A
SCHEMBL3394595 0.77 DPP4 (0.48) DPP4DPP8DPP9MAPTKMT2A
SCHEMBL13000980 0.77 DPP4 (0.48) DPP4DPP8DPP9MAPTKMT2A
SCHEMBL3395683 0.77 DPP4 (0.38) DPP4DPP8DPP9MAPTKMT2A
SCHEMBL2744355 0.77 DPP4 (0.38) DPP4DPP8DPP9MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8415349-B2 Dicycloazaalkane derivatives, preparation processes and medical uses thereof Jiangsu Hansoh Pharmaceuticals Co., Ltd. (CN) 2013-04-09 US disclosed
US-20130012705-A1 DICYCLOAZAALKANE DERIVATIVES, PREPARATION PROCESSES AND MEDICAL USES THEREOF JIANGSU HANSOH PHARMACEUTICAL CO., LTD. (CN) 2013-01-10 US disclosed
US-20130012705-A1 DICYCLOAZAALKANE DERIVATIVES, PREPARATION PROCESSES AND MEDICAL USES THEREOF JIANGSU HANSOH PHARMACEUTICAL CO., LTD. (CN) 2013-01-10 US disclosed
US-8304411-B2 Dicycloazaalkane derivates, preparation processes and medical uses thereof JIANGSU HANSOH PHARMACEUTICAL CO., LTD. (CN) 2012-11-06 US disclosed
US-8304411-B2 Dicycloazaalkane derivates, preparation processes and medical uses thereof JIANGSU HANSOH PHARMACEUTICAL CO., LTD. (CN) 2012-11-06 US disclosed
US-8178575-B2 Derivatives of azabicyclo octane, the method of making them and the uses thereof as inhibitors of dipeptidyl peptidase IV SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) 2012-05-15 US disclosed
US-8178575-B2 Derivatives of azabicyclo octane, the method of making them and the uses thereof as inhibitors of dipeptidyl peptidase IV SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) 2012-05-15 US disclosed
US-20100311747-A1 DICYCLOAZAALKANE DERIVATES, PREPARATION PROCESSES AND MEDICAL USES THEREOF SHANGHAI HENGRUI PHARMACEUTICAL CO. LTD. (CN) 2010-12-09 US disclosed
US-20100311747-A1 DICYCLOAZAALKANE DERIVATES, PREPARATION PROCESSES AND MEDICAL USES THEREOF SHANGHAI HENGRUI PHARMACEUTICAL CO. LTD. (CN) 2010-12-09 US disclosed
US-20100016314-A1 DERIVATIVES OF AZABICYCLO OCTANE, THE METHOD OF MAKING THEM AND THE USES THEREOF AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) 2010-01-21 US disclosed
US-20100016314-A1 DERIVATIVES OF AZABICYCLO OCTANE, THE METHOD OF MAKING THEM AND THE USES THEREOF AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) 2010-01-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100016314-A1 DERIVATIVES OF AZABICYCLO OCTANE, THE METHOD OF MAKING THEM AND THE USES THEREOF AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV DPP4, DPP3, DPP8 DPP4 1/4885DPP8 3/4885DPP9 5/4885
US-20130012705-A1 DICYCLOAZAALKANE DERIVATIVES, PREPARATION PROCESSES AND MEDICAL USES THEREOF DPP4, DPP8, DPP7 DPP4 1/4885DPP8 2/4885DPP9 5/4885
US-20100311747-A1 DICYCLOAZAALKANE DERIVATES, PREPARATION PROCESSES AND MEDICAL USES THEREOF DPP4, DPP8, DPP7 DPP4 1/4885DPP8 2/4885DPP9 5/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.