Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.73 |
| ▸ | PDE4A | P27815 | 11/20 | 0.73 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.73 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.73 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14576434 | 0.86 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL4527711 | 0.86 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5355274 | 0.85 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5359249 | 0.85 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL14576374 | 0.85 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5349267 | 0.85 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5756677 | 0.83 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5756669 | 0.83 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5360738 | 0.78 | PDE4B (0.46) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5362250 | 0.77 | PDE4B (0.46) | PDE4BPDE4APDE4CPDE4DPDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716871-B2 | OBESITY; INFLAMMATORY DISEASES, DISEASES INVOLVING ELEVATED LEVELS OF CYTOKINES, CENTRAL NERVOUS SYSTEM DISORDERS; 3-HYDROXYALKYL-4-DIALKOXYPHENYL-SUBSTITUTED PYRROLIDINES | ICOS CORPORATION | 2004-04-06 | — | — | US | disclosed |