Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Saredutant. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 known ✓ | P21452 | 14/20 | 1.00 |
| ▸ | TACR1 | P25103 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Saredutant SCHEMBL185911 | 1.00 | TACR2 (1.00) | TACR2TACR1 | |
| Saredutant SCHEMBL29371280 | 1.00 | TACR2 (1.00) | TACR2TACR1 | |
| Saredutant SCHEMBL9317902 | 0.99 | TACR2 (0.98) | TACR2TACR1 | |
| Saredutant SCHEMBL8592243 | 0.97 | TACR2 (0.94) | TACR2TACR1 | |
| Hydrochloric Acid SCHEMBL8369094 | 0.92 | TACR2 (0.85) | TACR2TACR1 | |
| Hydrochloric Acid SCHEMBL8369092 | 0.92 | TACR2 (0.85) | TACR2TACR1 | |
| Hydrochloric Acid SCHEMBL8369116 | 0.91 | TACR2 (0.84) | TACR2TACR1 | |
| Hydrochloric Acid SCHEMBL8369112 | 0.91 | TACR2 (0.84) | TACR2TACR1 | |
| Hydrochloric Acid SCHEMBL8539136 | 0.90 | TACR2 (0.82) | TACR2TACR1 | |
| Hydrochloric Acid SCHEMBL8366970 | 0.90 | TACR2 (0.81) | TACR2TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 210 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090795-A1 | Pharmaceutical Compositions Based on Nk2 Antagonists for Pediatric Use | LABORATORI GUIDOTTI S.P.A. (IT) | 2008-04-17 | — | — | US | claimed |
| EP-1809267-A1 | PHARMACEUTICAL COMPOSITIONS BASED ON NK2 ANTAGONISTS FOR PEDIATRIC USE | Laboratori Guidotti S.P.A. (IT) | 2007-07-25 | — | — | EP | claimed |
| WO-2006045820-A1 | PHARMACEUTICAL COMPOSITIONS BASED ON NK2 ANTAGONISTS FOR PEDIATRIC USE | LABORATORI GUIDOTTI S.P.A. (IT) | 2006-05-04 | — | — | WO | claimed |
| EP-0858325-B1 | STABLE FREEZE-DRIED PHARMACEUTICAL FORMULATION | SANOFI SYNTHELABO (FR) | 2002-07-31 | — | — | EP | claimed |
| US-6284277-B1 | NONPROTEIN | SANOFI-SYNTHELABO (FR) | 2001-09-04 | — | — | US | claimed |
| US-6254585-B1 | Surgical irrigation solution and method for inhibition of pain and inflammation | OMEROS MEDICAL SYSTEMS, INC. | 2001-07-03 | — | — | US | claimed |
| US-6177450-B1 | MIXTURE OF PERHYDROISOINDENE COMPOUND AND BENEZAMIDE COMPOUND | AVENTIS PHARMA S.A. | 2001-01-23 | — | — | US | claimed |
| EP-0474561-B1 | Arylalkylamines, process for their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1998-12-09 | — | — | EP | claimed |
| EP-0698601-B1 | Process for the preparation of the (-)-N-methyl-N-[4-(4-phenyl-4-acetyl-aminopiperidin-1-yl)-2-(3,4-dichlorophenyl)butyl]-benzamide and its pharmaceutically acceptable salts | SANOFI SA (FR) | 1998-11-04 | — | — | EP | claimed |
| US-5512680-A | Process for the preparation of an optically pure aminoalcohol | SANOFI (FR) | 1996-04-30 | — | — | US | claimed |
| EP-0698601-A1 | Process for the preparation of the (-)-N-methyl-N- 4-(4-phenyl-4-acetyl-aminopiperidin-1-yl)-2-(3,4-dichlorophenyl)butyl -benzamide and its pharmaceutically acceptable salts | SANOFI (FR) | 1996-02-28 | — | — | EP | claimed |
| US-5350852-A | Neurokinin A receptor antagonist | SANOFI (FR) | 1994-09-27 | — | — | US | claimed |
| US-5236921-A | Administrering for treatment of neutrogenic inflammation of the respiratory trart | SANOFI (FR) | 1993-08-17 | — | — | US | claimed |
| WO-1993014084-A2 | PIPERIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1993-07-22 | — | — | WO | claimed |
| JP-4261155-A | — | — | None | — | — | JP | disclosed |
| US-20220175797-A1 | OPHTHALMOLOGIC IRRIGATION SOLUTIONS AND METHOD | OMEROS CORP (US) | 2022-06-09 | — | — | US | disclosed |
| US-20170312295-A1 | Ophthalmologic Irrigation Solutions and Method | OMEROS CORP (US) | 2017-11-02 | — | — | US | disclosed |
| US-5236921-A | Administrering for treatment of neutrogenic inflammation of the respiratory trart | SANOFI (FR) | 1993-08-17 | — | — | US | disclosed |
| WO-1993014084-A2 | PIPERIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1993-07-22 | — | — | WO | disclosed |
| JP-H04261155-A | ARYLALKYLAMINES, THEIR PRODUCTION AND MEDICINE COMPOSITION CONTAINING THE SAME | SANOFI SA | 1992-09-17 | — | — | JP | disclosed |