Isoliquiritin

Isoliquiritin

SCHEMBL676338

O=C(/C=C/c1ccc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1)c1ccc(O)cc1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 3/20 1.00
DPP4 P27487 1/20 1.00
GAA P10253 2/20 0.63
TDP1 Q9NUW8 2/20 0.63
MAPT P10636 3/20 0.60
MAPK1 P28482 3/20 0.60
KDM4E B2RXH2 1/20 0.60
POLB P06746 1/20 0.60
G6PD P11413 1/20 0.60
ADRA1A P35348 1/20 0.60
PTGS2 P35354 1/20 0.60
TYR P14679 3/20 0.59
NPC1 O15118 1/20 0.55
RAB9A P51151 1/20 0.55
CYP3A4 P08684 3/20 0.55
MEN1 O00255 2/20 0.55
LMNA P02545 2/20 0.55
TP53 P04637 2/20 0.55
HPGD P15428 2/20 0.55
ALOX15 P16050 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isoliquiritin SCHEMBL25221453 1.00 AKR1B1 (1.00) AKR1B1DPP4GAATDP1MAPT
Isoliquiritin SCHEMBL25206709 1.00 AKR1B1 (1.00) AKR1B1DPP4GAATDP1MAPT
Isoliquiritin SCHEMBL30382387 1.00 AKR1B1 (1.00) AKR1B1DPP4GAATDP1MAPT
Isoliquiritin SCHEMBL25201715 1.00 AKR1B1 (1.00) AKR1B1DPP4GAATDP1MAPT
Isoliquiritin SCHEMBL25189174 1.00 AKR1B1 (1.00) AKR1B1DPP4GAATDP1MAPT
Isoliquiritin SCHEMBL25200366 1.00 AKR1B1 (1.00) AKR1B1DPP4GAATDP1MAPT
Isoliquiritin SCHEMBL25194416 1.00 AKR1B1 (1.00) AKR1B1DPP4GAATDP1MAPT
SCHEMBL25195327 0.96 AKR1B1 (0.92) AKR1B1DPP4GAATDP1MAPT
SCHEMBL25243573 0.96 AKR1B1 (0.92) AKR1B1DPP4GAATDP1MAPT
SCHEMBL25209851 0.95 AKR1B1 (0.90) AKR1B1DPP4GAATDP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1577 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025251988-A9 REAGENT COMBINATION OR KIT FOR CONSTRUCTING EMBRYOID AND USE THEREOF 广州国家实验室 2026-05-15 WO claimed
EP-4615506-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES Sahin, Fikret (TR) 2025-09-17 EP claimed
US-12329797-B2 Method for improving health condition of mammal or farm animal ONISHI TAKAO (JP) 2025-06-17 US claimed
US-20250177467-A1 COMPOSITIONS AND METHODS FOR MODULATING NUCLEAR FACTOR OF ACTIVATED T-CELLS (NFAT) ACTIVITY OF T CELLS UNIV YALE (US) 2025-06-05 US claimed
US-20250114421-A1 METHOD FOR IMPROVING HEALTH CONDITION OF MAMMAL OR FARM ANIMAL ONISHI TAKAO (JP) 2025-04-10 US claimed
US-20250108086-A1 LICORICE EXTRACT ONISHI TAKAO (JP) 2025-04-03 US claimed
EP-4486363-A1 COMPOSITIONS AND METHODS FOR MODULATING NUCLEAR FACTOR OF ACTIVATED T-CELLS (NFAT) ACTIVITY OF T CELLS Yale University (US) 2025-01-08 EP claimed
WO-2024258363-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES SAHIN FIKRET (TR) 2024-12-19 WO claimed
EP-4442124-A1 LICORICE EXTRACT Onishi, Takao (JP) 2024-10-09 EP claimed
EP-4442125-A1 METHOD FOR IMPROVING HEALTH CONDITION OF MAMMAL OR FARM ANIMAL Onishi, Takao (JP) 2024-10-09 EP claimed
WO-2003039452-A2 NUTRITIONAL SUPPLEMENTS AND METHODS FOR PREVENTION, REDUCTION AND TREATMENT OF RADIATION INJURY THE QUIGLEY CORPORATION (US) 2003-05-15 WO claimed
CN-1416881-A Medicine composition for treating depression and its prepn BEIJING TRADITIONAL CHINESE ME (CN) 2003-05-14 CN claimed
US-6555573-B2 Comprising a cold compounded mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor, antioxidant and carrier; side effect reduction; partial recovery of neurological function in some cases THE QUIGLEY CORPORATION 2003-04-29 US claimed
US-20020165207-A1 Compositions and methods for the treatment of diabetic neuropathy QUIGLEY CORPORATION, THE 2002-11-07 US claimed
US-20020115618-A1 Method and composition for the topical treatment of diabetic neuropathy QUIGLEY CORPORATION, THE 2002-08-22 US claimed
WO-2002049575-A2 METHOD AND COMPOSITION FOR THE TREATMENT OF DIABETIC NEUROPATHY THE QUIGLEY CORPORATION (US) 2002-06-27 WO claimed
CN-1348813-A Separation and preparation method of effective part and active component of anti-influenza virus medicine BEIJING TRADITIONAL CHINESE ME (CN) 2002-05-15 CN claimed
EP-0493611-B1 COMPOSITION FOR FUNCTIONAL FOOD AND MEDICAMENT PREPARED FROM LICORICE EXTRACT NIPPON HYPOX LAB INC (JP) 1997-11-26 EP claimed
US-5264421-A Lactic acid fermentation aqueous liquorice extract for antiulcer agents and hepatic diseases NIPPON HYPOX LABORATORIES, INCORPORATED (JP) 1993-11-23 US claimed
EP-0493611-A1 COMPOSITION FOR FUNCTIONAL FOOD PREPARED FROM LICORICE EXTRACT NIPPON HYPOX LABORATORIES INCORPORATED (JP) 1992-07-08 EP claimed