Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1SLC9A3
The experimentally established mechanism targets of L-Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 4/20 | 0.38 |
| ▸ | CA4 | P22748 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| L-Lactic Acid SCHEMBL8406685 | 0.97 | TP53 (0.44) | TP53CA1CA4CA2CYP3A4 | |
| L-Lactic Acid SCHEMBL31396146 | 0.97 | — | — | |
| L-Lactic Acid SCHEMBL29508838 | 0.96 | TP53 (0.50) | TP53CA1CA4CA2CYP3A4 | |
| L-Lactic Acid SCHEMBL21125 | 0.96 | TP53 (0.50) | TP53CA1CA4CA2CYP3A4 | |
| L-Lactic Acid SCHEMBL216080 | 0.96 | TP53 (0.50) | TP53CA1CA4CA2CYP3A4 | |
| L-Lactic Acid SCHEMBL10805780 | 0.96 | TP53 (0.50) | TP53CA1CA4CA2CYP3A4 | |
| L-Lactic Acid SCHEMBL29682730 | 0.96 | TP53 (0.50) | TP53CA1CA4CA2CYP3A4 | |
| L-Lactic Acid SCHEMBL223994 | 0.93 | TP53 (0.47) | TP53CA1CA4CA2CYP3A4 | |
| L-Lactic Acid SCHEMBL1264937 | 0.93 | TP53 (0.47) | TP53CA1CA4CA2CYP3A4 | |
| L-Lactic Acid SCHEMBL9055912 | 0.93 | TP53 (0.47) | TP53CA1CA4CA2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104136498-B | Novel liquid organopolysiloxanes and use thereof | 道康宁东丽株式会社 | 2017-06-20 | — | — | CN | disclosed |
| CN-103619914-B | Organopolysiloxane elastomers and utilization thereof | 道康宁东丽株式会社 | 2016-09-07 | — | — | CN | disclosed |
| CN-103608384-B | Liquid organopolysiloxane and use thereof | 道康宁东丽株式会社 | 2016-08-31 | — | — | CN | disclosed |
| CN-102666664-B | The organopolysiloxane of modification altogether | DOW CORNING TORAY CO.,LTD. (JP) | 2015-09-23 | — | — | CN | disclosed |
| CN-102648264-B | Thickening or gelling agent for oil-based raw materials | DOW CORNING TORAY CO.,LTD. (JP) | 2015-08-19 | — | — | CN | disclosed |
| CN-104136498-A | Novel liquid organopolysiloxanes and use thereof | DOW CORNING TORAY CO LTD | 2014-11-05 | — | — | CN | disclosed |
| CN-103619914-A | Novel organopolysiloxane elastomer and use therefor | DOW CORNING TORAY CO LTD | 2014-03-05 | — | — | CN | disclosed |
| CN-103608384-A | Novel liquid organopolysiloxane and use thereof | DOW CORNING TORAY CO LTD | 2014-02-26 | — | — | CN | disclosed |
| CN-102666664-A | Novel co-modified organopolysiloxane | DOW CORNING TORAY CO LTD | 2012-09-12 | — | — | CN | disclosed |
| CN-102666663-A | Novel organopolysiloxane copolymer | DOW CORNING TORAY CO LTD | 2012-09-12 | — | — | CN | disclosed |
| EP-0537003-B1 | Silicone polyether alkyl copolymers | GEN ELECTRIC (US) | 1998-01-07 | — | — | EP | disclosed |
| US-5539136-A | Silicone polyether surfactants synthesized using carbamate linkage | GENERAL ELECTRIC COMPANY (US) | 1996-07-23 | — | — | US | disclosed |
| US-5456906-A | Transparent | GENERAL ELECTRIC COMPANY (US) | 1995-10-10 | — | — | US | disclosed |
| US-5451692-A | Silicone polyether alkyl copolymer synthesis | GENERAL ELECTRIC COMPANY (US) | 1995-09-19 | — | — | US | disclosed |
| US-5401870-A | Emulsifiers for stable water in oil emulsions | GENERAL ELECTRIC COMPANY (US) | 1995-03-28 | — | — | US | disclosed |
| EP-0585044-A2 | Silicone polyether surfactants | GENERAL ELECTRIC COMPANY (US) | 1994-03-02 | — | — | EP | disclosed |
| EP-0537003-A1 | Silicone polyether alkyl copolymers | GENERAL ELECTRIC COMPANY (US) | 1993-04-14 | — | — | EP | disclosed |
| EP-0373424-B1 | ANTIPERSPIRANT COMPOSITIONS | GENERAL ELECTRIC COMPANY (US) | 1993-01-20 | — | — | EP | disclosed |
| US-4980156-A | ASTRINGENT EMULSIFIED IN SILICON FLUID | GENERAL ELECTRIC COMPANY (US) | 1990-12-25 | — | — | US | disclosed |
| EP-0373424-A2 | Antiperspirant compositions | GENERAL ELECTRIC COMPANY (US) | 1990-06-20 | — | — | EP | disclosed |