Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 11/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 8/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.43 |
| ▸ | CIT | O14578 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | STK16 | O75716 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.40 |
| ▸ | CDK11B | P21127 | 1/20 | 0.40 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPK4 | P31152 | 1/20 | 0.40 |
| ▸ | TTK | P33981 | 1/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.40 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5096812 | 0.83 | ROCK1 (0.49) | ROCK1ALDH1A1MAPT | |
| SCHEMBL5102668 | 0.83 | MAPK8 (0.48) | ROCK1MAPK8MAPK9MAPK10MKNK1 | |
| SCHEMBL5102627 | 0.82 | ROCK1 (0.72) | ROCK1MAPK8MAPK9MAPK10MAPK1 | |
| SCHEMBL5102434 | 0.81 | ROCK1 (0.42) | ROCK1 | |
| SCHEMBL5102192 | 0.79 | ROCK1 (0.45) | ROCK1MAPK8MAPK9MAPK10ALDH1A1 | |
| SCHEMBL5096164 | 0.77 | ROCK1 (0.45) | ROCK1MAPK8MAPK9MAPK10CIT | |
| SCHEMBL5102138 | 0.77 | ROCK1 (0.41) | ROCK1ALDH1A1MAPT | |
| SCHEMBL5096259 | 0.76 | MAPT (0.44) | ROCK1ALDH1A1MAPT | |
| SCHEMBL1163857 | 0.76 | ROCK1 (0.40) | ROCK1ALDH1A1MAPT | |
| SCHEMBL5096582 | 0.76 | MAPT (0.41) | ROCK1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576537-B1 | 2-AMINO-PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF JNK | HOFFMANN LA ROCHE (CH) | 2016-03-16 | — | — | EP | disclosed |
| EP-2576537-B1 | 2-AMINO-PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF JNK | HOFFMANN LA ROCHE (CH) | 2016-03-16 | — | — | EP | disclosed |
| EP-2576559-B1 | INHIBITORS OF JNK | HOFFMANN LA ROCHE (CH) | 2015-03-04 | — | — | EP | disclosed |
| EP-2576559-B1 | INHIBITORS OF JNK | HOFFMANN LA ROCHE (CH) | 2015-03-04 | — | — | EP | disclosed |
| US-8642601-B2 | Inhibitors of JNK | ROCHE PALO ALTO LLC (US) | 2014-02-04 | — | — | US | disclosed |
| US-8642601-B2 | Inhibitors of JNK | ROCHE PALO ALTO LLC (US) | 2014-02-04 | — | — | US | disclosed |
| US-8642601-B2 | Inhibitors of JNK | ROCHE PALO ALTO LLC (US) | 2014-02-04 | — | — | US | disclosed |
| EP-2576559-A1 | INHIBITORS OF JNK | F.HOFFMANN-LA ROCHE AG (CH) | 2013-04-10 | — | — | EP | disclosed |
| EP-2576537-A1 | 2 -AMINO- PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF JNK | F.HOFFMANN-LA ROCHE AG (CH) | 2013-04-10 | — | — | EP | disclosed |
| US-8183254-B2 | Inhibitors of JNK | ROCHE PALO ALTO LLC (US) | 2012-05-22 | — | — | US | disclosed |
| US-20110301171-A1 | Inhibitors of JNK | ARZENO HUMBERTO BARTOLOME (US) | 2011-12-08 | — | — | US | disclosed |
| US-20110301171-A1 | Inhibitors of JNK | ARZENO HUMBERTO BARTOLOME (US) | 2011-12-08 | — | — | US | disclosed |
| WO-2011151357-A1 | INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-08 | — | — | WO | disclosed |
| WO-2011151358-A1 | 2 -AMINO- PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-08 | — | — | WO | disclosed |
| US-20110301170-A1 | Inhibitors of JNK | GONG LEYI (US) | 2011-12-08 | — | — | US | disclosed |
| US-20110301170-A1 | Inhibitors of JNK | GONG LEYI (US) | 2011-12-08 | — | — | US | disclosed |
| WO-2011151357-A1 | INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-08 | — | — | WO | disclosed |
| US-20110301170-A1 | Inhibitors of JNK | GONG LEYI (US) | 2011-12-08 | — | — | US | disclosed |
| US-20090318484-A1 | Inhibitors of JNK | ROCHE PALO ALTO LLC | 2009-12-24 | — | — | US | disclosed |
| US-20090318484-A1 | Inhibitors of JNK | ROCHE PALO ALTO LLC | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318484-A1 | Inhibitors of JNK | MAPK1, MAP3K6, MAP3K1 | ROCK1 144/4885MAPK8 36/4885MAPK9 30/4885 |
| US-20110301170-A1 | Inhibitors of JNK | MAPK6, MAP3K6, MAPK1 | ROCK1 181/4885MAPK8 35/4885MAPK9 11/4885 |
| US-20110301171-A1 | Inhibitors of JNK | MAPK9, MAP3K9, MAPK1 | ROCK1 130/4885MAPK8 28/4885MAPK9 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.