Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.64 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | SGK1 | O00141 | 6/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.32 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.32 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2489644 | 0.84 | CYP3A4 (0.73) | CYP3A4CRBNERBB2PADI4PIP4K2A | |
| SCHEMBL2489645 | 0.84 | CYP3A4 (0.73) | CYP3A4CRBNERBB2PADI4PIP4K2A | |
| SCHEMBL1764618 | 0.83 | CYP3A4 (0.65) | CYP3A4CRBNPADI4PIP4K2APIP4K2B | |
| SCHEMBL1764614 | 0.83 | CYP3A4 (0.65) | CYP3A4CRBNPADI4PIP4K2APIP4K2B | |
| SCHEMBL2488809 | 0.83 | CYP3A4 (0.43) | CYP3A4SGK1CCNE2CCNE1CDK2 | |
| SCHEMBL2488811 | 0.83 | CYP3A4 (0.43) | CYP3A4SGK1CCNE2CCNE1CDK2 | |
| SCHEMBL2489282 | 0.82 | CYP3A4 (0.68) | CYP3A4CRBNSGK1ERBB2PADI4 | |
| SCHEMBL2489284 | 0.82 | CYP3A4 (0.68) | CYP3A4CRBNSGK1ERBB2PADI4 | |
| SCHEMBL1542848 | 0.81 | CYP3A4 (0.76) | CYP3A4CRBNERBB2PADI4 | |
| SCHEMBL2130293 | 0.81 | CYP3A4 (0.76) | CYP3A4CRBNERBB2PADI4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178547-B2 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC (US) | 2012-05-15 | — | — | US | disclosed |
| US-20100158860-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | STEINER SANDRA | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100158860-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | RFC1, RRP1B, RRBP1 | CYP3A4 978/4885CRBN 1341/4885SGK1 4754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.