Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 16/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 14/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 14/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 14/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6767575 | 0.87 | PIK3CA (0.59) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL5757489 | 0.86 | PIK3CA (0.54) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL5755728 | 0.84 | MAPK1 (0.50) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL5759755 | 0.84 | MAPK1 (0.50) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL4697024 | 0.83 | MAPK1 (0.56) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| Hydrochloric Acid SCHEMBL5623610 | 0.82 | MAPK1 (0.55) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL5758308 | 0.81 | MAPK1 (0.56) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL5759669 | 0.81 | MAPK1 (0.47) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL5758759 | 0.79 | BCHE (0.50) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL5761406 | 0.78 | MAPK1 (0.57) | PIK3CAMAPK1MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6727252-B1 | THE SERINE/THREONINE KINASE FAMILY INCLUDES MEMBERS THAT REGULATE CELL GROWTH, MIGRATION, DIFFERENTIATION, GENE EXPRESSION, MUSCLE CONTRACTION, GLUCOSE METABOLISM, CELLULAR PROTEIN SYNTHESIS, AND REGULATION OF THE CELL CYCLE | ZENTARIS AG (DE) | 2004-04-27 | — | — | US | disclosed |