Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 19/20 | 0.67 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5759771 | 0.92 | MAPK1 (0.55) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL5758226 | 0.88 | MAPK1 (0.60) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL12970878 | 0.80 | MAPK1 (1.00) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL4697024 | 0.79 | MAPK1 (0.56) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL5755308 | 0.78 | MAPK1 (0.55) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| Hydrochloric Acid SCHEMBL5623610 | 0.78 | MAPK1 (0.55) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL5758853 | 0.78 | MAPK1 (0.53) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL5756147 | 0.78 | MAPK1 (0.50) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL5759670 | 0.78 | MAPK1 (0.52) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL5757683 | 0.78 | MAPK1 (0.56) | MAPK1PIK3CAMAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6727252-B1 | THE SERINE/THREONINE KINASE FAMILY INCLUDES MEMBERS THAT REGULATE CELL GROWTH, MIGRATION, DIFFERENTIATION, GENE EXPRESSION, MUSCLE CONTRACTION, GLUCOSE METABOLISM, CELLULAR PROTEIN SYNTHESIS, AND REGULATION OF THE CELL CYCLE | ZENTARIS AG (DE) | 2004-04-27 | — | — | US | disclosed |
| US-6180631-B1 | PREVENTING AND TREATING SERINE/THREONINE PROTEIN KINASE-RELATED ABNORMAL CONDITIONS IN MAMMALS ASSOCIATED WITH AN ABERRATION IN A SIGNAL TRANSDUCTION PATHWAY SUCH AS CANCER OR A FIBROTIC DISORDER | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 2001-01-30 | — | — | US | disclosed |