Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.61 |
| ▸ | MAPK13 | O15264 | 11/20 | 0.61 |
| ▸ | MAPK12 | P53778 | 11/20 | 0.61 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | BRD2 | P25440 | 2/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.43 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6763952 | 0.96 | MAPK14 (0.54) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL6768619 | 0.93 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL6769365 | 0.92 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL6767240 | 0.91 | MAPK14 (0.50) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL6768682 | 0.90 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11BRD4 | |
| SCHEMBL6768667 | 0.89 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11BRD4 | |
| SCHEMBL6621254 | 0.85 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6621251 | 0.85 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6618659 | 0.82 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11BRD4 | |
| SCHEMBL6619056 | 0.82 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677337-B2 | RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, INFLAMMATORY BOWEL DISEASE, CACHEXIA, SEPTIC SHOCK, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | THE PROCTER & GAMBLE COMPANY | 2004-01-13 | — | — | US | claimed |