Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 18/20 | 0.48 |
| ▸ | EGFR | P00533 | 16/20 | 0.48 |
| ▸ | ERBB4 | Q15303 | 12/20 | 0.47 |
| ▸ | JAK3 | P52333 | 8/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RGS12 | O14924 | 1/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4533042 | 0.93 | ERBB2 (0.55) | ERBB2EGFRERBB4JAK3MEN1 | |
| SCHEMBL6768225 | 0.91 | ERBB2 (0.48) | ERBB2EGFRERBB4JAK3MEN1 | |
| SCHEMBL6767483 | 0.89 | ERBB2 (0.48) | ERBB2EGFRERBB4JAK3MEN1 | |
| SCHEMBL6768728 | 0.84 | ERBB2 (0.54) | ERBB2EGFRERBB4JAK3MEN1 | |
| SCHEMBL7517989 | 0.83 | ERBB2 (0.66) | ERBB2EGFRERBB4JAK3MEN1 | |
| SCHEMBL4534051 | 0.83 | ERBB2 (0.54) | ERBB2EGFRERBB4JAK3MEN1 | |
| SCHEMBL6768670 | 0.81 | ERBB2 (0.54) | ERBB2EGFRERBB4JAK3MEN1 | |
| SCHEMBL6766568 | 0.81 | ERBB2 (0.63) | ERBB2EGFRERBB4JAK3MEN1 | |
| SCHEMBL6764001 | 0.79 | ERBB2 (0.65) | ERBB2EGFRERBB4JAK3MEN1 | |
| SCHEMBL6889749 | 0.78 | ERBB2 (0.65) | ERBB2EGFRERBB4JAK3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828320-B2 | Enzyme inhibitors; anticancer agents | SMITHKLINE BEECHAM CORPORATION | 2004-12-07 | — | — | US | disclosed |
| US-6391874-B1 | ANTICARCINOGENIC AGENTS; SKIN DISORDERS | SMITHKLINE BEECHAM CORPORATION | 2002-05-21 | — | — | US | disclosed |