Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.67 |
| ▸ | MAPK13 | O15264 | 10/20 | 0.67 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.67 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.67 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | LYN | P07948 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | AKT2 | P31751 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | FRK | P42685 | 1/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.50 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6766662 | 0.91 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11PRKD3 | |
| SCHEMBL6622700 | 0.91 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11PRKD3 | |
| SCHEMBL6622935 | 0.91 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11PRKD3 | |
| SCHEMBL6622775 | 0.90 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11PRKD3 | |
| SCHEMBL6623935 | 0.90 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11PRKD3 | |
| SCHEMBL6623936 | 0.89 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11PRKD3 | |
| SCHEMBL6680026 | 0.88 | MAPK14 (0.57) | MAPK14MAPK13MAPK12MAPK11PRKD3 | |
| SCHEMBL6667518 | 0.87 | MAPK14 (0.57) | MAPK14MAPK13MAPK12MAPK11PRKD3 | |
| SCHEMBL7251949 | 0.87 | MAPK14 (0.57) | MAPK14MAPK13MAPK12MAPK11PRKD3 | |
| SCHEMBL6622862 | 0.86 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677337-B2 | RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, INFLAMMATORY BOWEL DISEASE, CACHEXIA, SEPTIC SHOCK, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | THE PROCTER & GAMBLE COMPANY | 2004-01-13 | — | — | US | disclosed |