Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PTGFR | P43088 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3156104 | 1.00 | BACE1 (0.45) | BACE1MEN1KMT2ATP53CCNB2 | |
| SCHEMBL3157774 | 0.93 | PLAU (0.46) | BACE1MEN1KMT2ATP53PLAU | |
| SCHEMBL3157766 | 0.93 | PLAU (0.46) | BACE1MEN1KMT2ATP53PLAU | |
| SCHEMBL6770244 | 0.92 | BACE1 (0.46) | BACE1MEN1KMT2ATP53CCNB2 | |
| SCHEMBL3143475 | 0.92 | BACE1 (0.46) | BACE1MEN1KMT2ATP53CCNB2 | |
| SCHEMBL2570441 | 0.92 | BACE1 (0.46) | BACE1MEN1KMT2ATP53PLAU | |
| SCHEMBL2570438 | 0.92 | BACE1 (0.46) | BACE1MEN1KMT2ATP53PLAU | |
| SCHEMBL2571183 | 0.91 | BACE1 (0.45) | BACE1MEN1KMT2ATP53PLAU | |
| SCHEMBL2571179 | 0.91 | BACE1 (0.45) | BACE1MEN1KMT2ATP53PLAU | |
| SCHEMBL3143730 | 0.90 | MAPT (0.47) | BACE1MEN1KMT2ATP53PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6762180-B1 | Substituted indolines which inhibit receptor tyrosine kinases | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2004-07-13 | — | — | US | disclosed |