Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 7/20 | 0.39 |
| ▸ | EDNRA | P25101 | 7/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961387 | 0.93 | POLB (0.39) | EDNRBEDNRATP53MAPT | |
| SCHEMBL6640800 | 0.92 | EDNRB (0.41) | EDNRBEDNRATP53MAPT | |
| SCHEMBL6778008 | 0.90 | EDNRB (0.40) | EDNRBEDNRATP53MAPT | |
| SCHEMBL6770266 | 0.90 | EDNRB (0.39) | EDNRBEDNRATP53MAPT | |
| SCHEMBL8062314 | 0.90 | EDNRB (0.38) | EDNRBEDNRA | |
| SCHEMBL6772130 | 0.89 | TP53 (0.39) | EDNRBEDNRATP53MAPT | |
| SCHEMBL6642156 | 0.88 | EDNRA (0.39) | EDNRBEDNRATP53MAPT | |
| SCHEMBL4774144 | 0.88 | TP53 (0.39) | EDNRBEDNRATP53MAPT | |
| SCHEMBL8568832 | 0.88 | EDNRA (0.52) | EDNRBEDNRA | |
| SCHEMBL4770889 | 0.88 | EDNRB (0.40) | EDNRBEDNRATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673824-B1 | HYPOTENSIVE AGENTS | BRISTOL-MYERS SQUIBB CO. | 2004-01-06 | — | — | US | disclosed |
| US-6107320-A | Phenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0569193-B1 | N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-02-26 | — | — | EP | disclosed |
| US-5514696-A | Phenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 1996-05-07 | — | — | US | disclosed |