Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 16/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | PDE1A | P54750 | 2/20 | 0.52 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.52 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PDE6C | P51160 | 2/20 | 0.49 |
| ▸ | PDE2A | O00408 | 1/20 | 0.49 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.49 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.49 |
| ▸ | PDE6D | O43924 | 1/20 | 0.49 |
| ▸ | PDE8A | O60658 | 1/20 | 0.49 |
| ▸ | PDE9A | O76083 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6777800 | 0.89 | PDE5A (0.55) | PDE5AKMT2APDE1APDE1BPDE1C | |
| SCHEMBL6778560 | 0.85 | PDE5A (0.58) | PDE5AKMT2APDE1APDE1BPDE1C | |
| SCHEMBL6782391 | 0.84 | PDE5A (0.61) | PDE5AKMT2APDE1APDE1BPDE1C | |
| SCHEMBL6778664 | 0.84 | PDE5A (0.57) | PDE5AKMT2APDE1APDE1BPDE1C | |
| SCHEMBL6777005 | 0.81 | PDE5A (0.55) | PDE5AKMT2APDE1APDE1BPDE1C | |
| SCHEMBL6777057 | 0.80 | PDE5A (0.53) | PDE5AKMT2APDE1APDE1BPDE1C | |
| SCHEMBL6778276 | 0.79 | PDE5A (0.51) | PDE5AKMT2APDE1APDE1BPDE1C | |
| SCHEMBL6778750 | 0.79 | PDE5A (0.56) | PDE5AKMT2APDE1APDE1BPDE1C | |
| SCHEMBL6772542 | 0.79 | PDE5A (0.52) | PDE5AKMT2APDE1APDE1BPDE1C | |
| SCHEMBL6773154 | 0.79 | PDE5A (0.55) | PDE5AKMT2APDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756373-B1 | SUCH AS 5-(2-BUTOXY-5-IODO-3-PYRIDINYL)-3-ETHYL-2-(2-METHOXY-ETHYL)-2,6-DIHYDRO-7H -PYRAZOLO(4,3-D)PYRIMIDIN-7-ONE; CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE INHIBITORS; ERECTILE DYSFUNCTION | PFIZER INC. | 2004-06-29 | — | — | US | disclosed |