Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 10/20 | 0.74 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.66 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.66 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.66 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.50 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6774961 | 0.94 | CCR3 (0.75) | CCR3SLC6A4SLC6A2SLC6A3ROCK2 | |
| SCHEMBL6774966 | 0.94 | CCR3 (0.75) | CCR3SLC6A4SLC6A2SLC6A3ROCK2 | |
| SCHEMBL18840912 | 0.85 | CCR3 (1.00) | CCR3SLC6A4SLC6A2SLC6A3ROCK2 | |
| SCHEMBL7657805 | 0.85 | CCR3 (1.00) | CCR3SLC6A4SLC6A2SLC6A3ROCK2 | |
| SCHEMBL7657809 | 0.85 | CCR3 (1.00) | CCR3SLC6A4SLC6A2SLC6A3ROCK2 | |
| SCHEMBL6774752 | 0.81 | CCR3 (0.68) | CCR3SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL6774750 | 0.81 | CCR3 (0.68) | CCR3SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL6780550 | 0.80 | CCR3 (1.00) | CCR3SLC6A4SLC6A2SLC6A3HTR2A | |
| SCHEMBL6780545 | 0.80 | CCR3 (1.00) | CCR3SLC6A4SLC6A2SLC6A3HTR2A | |
| SCHEMBL7656814 | 0.79 | CCR3 (1.00) | CCR3SLC6A4SLC6A2SLC6A3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6706735-B2 | NITROGEN COMPOUNDS SUCH AS N-(3-(4-BENZYL-2-PIPERIDINYL)PROPYL )-N'-(3-CYANOPHENYL)UREA, USED AS CHEMOTACTIC CYTOKINE CONTROLLERS ADMINISTERED FOR PROPHYLAXIS OF ASTHMA, ALLERGIES AND AUTOIMMUNE DISEASES | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-03-16 | — | — | US | disclosed |