Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6772837 | 0.96 | PDE5A (1.00) | PDE5APDE6C | |
| SCHEMBL2407731 | 0.92 | PDE5A (1.00) | PDE5APDE6C | |
| SCHEMBL6777243 | 0.91 | PDE5A (1.00) | PDE5APDE6C | |
| SCHEMBL6783169 | 0.91 | PDE5A (0.87) | PDE5APDE6C | |
| SCHEMBL6771870 | 0.91 | PDE5A (1.00) | PDE5APDE6C | |
| SCHEMBL6776828 | 0.89 | PDE5A (1.00) | PDE5APDE6C | |
| SCHEMBL2404254 | 0.89 | PDE5A (1.00) | PDE5APDE6C | |
| SCHEMBL6776131 | 0.89 | PDE5A (0.86) | PDE5APDE6C | |
| SCHEMBL2032658 | 0.88 | PDE5A (0.79) | PDE5APDE6C | |
| SCHEMBL6359521 | 0.88 | PDE5A (1.00) | PDE5APDE6C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756373-B1 | SUCH AS 5-(2-BUTOXY-5-IODO-3-PYRIDINYL)-3-ETHYL-2-(2-METHOXY-ETHYL)-2,6-DIHYDRO-7H -PYRAZOLO(4,3-D)PYRIMIDIN-7-ONE; CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE INHIBITORS; ERECTILE DYSFUNCTION | PFIZER INC. | 2004-06-29 | — | — | US | disclosed |
| EP-1222190-A1 | 5-(2-SUBSTITUTED-5-HETEROCYCLYLSULPHONYLPYRID-3-YL)-DIHYDROPYRAZOLO[4,3-D]PYRIMIDIN-7-ONES AS PHOSPHODIESTERASE INHIBITORS | Pfizer Limited (GB) | 2002-07-17 | — | — | EP | disclosed |
| WO-2001027112-A1 | 5-(2-SUBSTITUTED-5-HETEROCYCLYLSULPHONYLPYRID-3-YL)-DIHYDROPYRAZOLO[4,3-D]PYRIMIDIN-7-ONES AS PHOSPHODIESTERASE INHIBITORS | PFIZER LIMITED (GB) | 2001-04-19 | — | — | WO | disclosed |