Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | PDE1A | P54750 | 2/20 | 0.59 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.59 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PDE2A | O00408 | 1/20 | 0.47 |
| ▸ | PDE6D | O43924 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | PDE9A | O76083 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | PDE6A | P16499 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6334405 | 0.91 | PDE5A (0.64) | PDE5AMEN1ALDH1A1HPGDPDE1A | |
| SCHEMBL6332363 | 0.87 | PDE5A (0.50) | PDE5AMEN1ALDH1A1HPGDPDE1A | |
| SCHEMBL6330883 | 0.85 | PDE5A (0.61) | PDE5AMEN1ALDH1A1HPGDPDE1A | |
| SCHEMBL6338891 | 0.84 | PDE5A (0.60) | PDE5AMEN1ALDH1A1HPGDPDE1A | |
| SCHEMBL6330296 | 0.83 | PDE5A (0.66) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL6330380 | 0.82 | PDE5A (0.59) | PDE5AMEN1ALDH1A1HPGDPDE1A | |
| SCHEMBL6338643 | 0.82 | PDE5A (0.61) | PDE5AMEN1ALDH1A1HPGDPDE1A | |
| SCHEMBL6332281 | 0.82 | PDE5A (0.61) | PDE5AMEN1ALDH1A1HPGDPDE1A | |
| SCHEMBL6332532 | 0.82 | PDE5A (0.67) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL6332949 | 0.82 | PDE5A (0.65) | PDE5AMEN1ALDH1A1HPGDPDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6723719-B1 | DYSMENORRHOEA, BENIGN PROSTATIC HYPERPLASIA (BPH), BLADDER OUTLET OBSTRUCTION, INCONTINENCE, AGINA, CONGESTIVE HEART FAILURE, ATHEROSCLEROSIS; HYPOTENSIVE AND ANTIALLERGEN AGENTS | PFIZER INC | 2004-04-20 | — | — | US | disclosed |