Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 9/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.48 |
| ▸ | CDK2 | P24941 | 5/20 | 0.48 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | CCNH | P51946 | 1/20 | 0.47 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.46 |
| ▸ | CLK1 | P49759 | 4/20 | 0.46 |
| ▸ | CLK2 | P49760 | 4/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6770594 | 0.94 | CDK1 (0.55) | CDK1CCNE1CDK2CCNE2CCNA2 | |
| SCHEMBL6770758 | 0.94 | CDK1 (0.56) | CDK1CCNE1CDK2CCNE2CCNA2 | |
| SCHEMBL6775328 | 0.93 | CDK1 (0.60) | CDK1CCNE1CDK2CCNE2CCNA2 | |
| SCHEMBL6770841 | 0.92 | CDK1 (0.55) | CDK1CCNE1CDK2CCNE2CCNA2 | |
| SCHEMBL6576950 | 0.89 | CDK1 (0.71) | CDK1CCNE1CDK2CCNB1 | |
| SCHEMBL6576509 | 0.89 | CDK1 (0.71) | CDK1CCNE1CDK2CCNB1 | |
| SCHEMBL6574743 | 0.82 | CDK1 (0.67) | CDK1CCNE1CDK2CCNA2CDK5 | |
| SCHEMBL6574741 | 0.82 | CDK1 (0.67) | CDK1CCNE1CDK2CCNA2CDK5 | |
| SCHEMBL6574902 | 0.82 | CDK1 (0.71) | CDK1CCNE1CDK2CCNB1 | |
| SCHEMBL6574904 | 0.82 | CDK1 (0.71) | CDK1CCNE1CDK2CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6767906-B2 | INHIBIT P34CDC2/CYCLIN BCDC13 KINASE AND PROTEIN TYROSINE KINASE PP60C-SRC AND CAN BE USED FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES, FOR EXAMPLE CHEMOTHERAPY OF TUMOURS OR OSTEOPOROSIS. | NOVARTIS AG (CH) | 2004-07-27 | — | — | US | claimed |