Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | PDE6C | P51160 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6777541 | 0.88 | PDE5A (0.59) | PDE5APDE6C | |
| SCHEMBL6773144 | 0.85 | PDE5A (0.59) | PDE5APDE6C | |
| SCHEMBL6774694 | 0.84 | PDE5A (0.46) | PDE5AHDAC1PDE6C | |
| SCHEMBL6357254 | 0.84 | PDE5A (0.55) | PDE5APDE6C | |
| SCHEMBL6778664 | 0.80 | PDE5A (0.57) | PDE5AHDAC1PDE6C | |
| SCHEMBL6777649 | 0.80 | PDE5A (0.60) | PDE5APDE6C | |
| SCHEMBL6359205 | 0.77 | PDE5A (0.43) | PDE5APDE6C | |
| SCHEMBL6777517 | 0.75 | PDE5A (0.71) | PDE5APDE6C | |
| SCHEMBL6776251 | 0.75 | PDE5A (0.58) | PDE5APDE6C | |
| SCHEMBL2405922 | 0.74 | PDE5A (0.69) | PDE5APDE6C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756373-B1 | SUCH AS 5-(2-BUTOXY-5-IODO-3-PYRIDINYL)-3-ETHYL-2-(2-METHOXY-ETHYL)-2,6-DIHYDRO-7H -PYRAZOLO(4,3-D)PYRIMIDIN-7-ONE; CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE INHIBITORS; ERECTILE DYSFUNCTION | PFIZER INC. | 2004-06-29 | — | — | US | claimed |
| US-6756373-B1 | SUCH AS 5-(2-BUTOXY-5-IODO-3-PYRIDINYL)-3-ETHYL-2-(2-METHOXY-ETHYL)-2,6-DIHYDRO-7H -PYRAZOLO(4,3-D)PYRIMIDIN-7-ONE; CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE INHIBITORS; ERECTILE DYSFUNCTION | PFIZER INC. | 2004-06-29 | — | — | US | disclosed |