Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 17/20 | 0.58 |
| ▸ | PDE6C | P51160 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6363110 | 0.93 | PDE5A (0.59) | PDE5APDE6C | |
| SCHEMBL6358925 | 0.87 | PDE5A (0.66) | PDE5APDE6C | |
| SCHEMBL6356946 | 0.83 | PDE5A (0.52) | PDE5ACCNA2CDK2CCNA1AURKA | |
| SCHEMBL6782080 | 0.82 | PDE5A (0.48) | PDE5ACDK2 | |
| SCHEMBL6379410 | 0.76 | PDE5A (0.43) | PDE5ACCNA2CDK2 | |
| SCHEMBL3573368 | 0.76 | PDE5A (0.88) | PDE5A | |
| SCHEMBL2402678 | 0.76 | PDE5A (0.53) | PDE5APDE6C | |
| SCHEMBL6202135 | 0.76 | PDE5A (0.45) | PDE5AMAPT | |
| SCHEMBL2405246 | 0.76 | PDE5A (0.92) | PDE5A | |
| SCHEMBL2404353 | 0.75 | PDE5A (0.79) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756373-B1 | SUCH AS 5-(2-BUTOXY-5-IODO-3-PYRIDINYL)-3-ETHYL-2-(2-METHOXY-ETHYL)-2,6-DIHYDRO-7H -PYRAZOLO(4,3-D)PYRIMIDIN-7-ONE; CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE INHIBITORS; ERECTILE DYSFUNCTION | PFIZER INC. | 2004-06-29 | — | — | US | disclosed |