Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.44 |
| ▸ | PDE6C | P51160 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6778002 | 0.90 | PDE5A (0.44) | PDE5AMTORHDAC1 | |
| SCHEMBL6781913 | 0.87 | PDE5A (0.58) | PDE5APDE6C | |
| SCHEMBL6774694 | 0.87 | PDE5A (0.46) | PDE5APDE6CMTORHDAC1 | |
| SCHEMBL6746647 | 0.86 | PDE5A (0.59) | PDE5A | |
| SCHEMBL6776251 | 0.85 | PDE5A (0.58) | PDE5APDE6C | |
| SCHEMBL6777156 | 0.83 | PDE5A (0.53) | PDE5APDE6C | |
| SCHEMBL6776709 | 0.78 | PDE5A (0.58) | PDE5APDE6C | |
| SCHEMBL6776186 | 0.76 | PDE5A (0.66) | PDE5APDE6C | |
| SCHEMBL6747096 | 0.76 | PDE5A (0.58) | PDE5A | |
| SCHEMBL6777649 | 0.75 | PDE5A (0.60) | PDE5APDE6C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756373-B1 | SUCH AS 5-(2-BUTOXY-5-IODO-3-PYRIDINYL)-3-ETHYL-2-(2-METHOXY-ETHYL)-2,6-DIHYDRO-7H -PYRAZOLO(4,3-D)PYRIMIDIN-7-ONE; CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE INHIBITORS; ERECTILE DYSFUNCTION | PFIZER INC. | 2004-06-29 | — | — | US | disclosed |