Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 4/20 | 0.51 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6329680 | 0.91 | RET (0.49) | RETTLK2NTRK1BRD4MAPT | |
| SCHEMBL6333337 | 0.90 | RET (0.57) | RETTLK2BRD4MAPTHIF1A | |
| SCHEMBL6778312 | 0.88 | RET (0.45) | RETTLK2NTRK1BRD4 | |
| SCHEMBL6333166 | 0.87 | RET (0.44) | RETTLK2NTRK1BRD4 | |
| SCHEMBL6340156 | 0.86 | RET (0.48) | RETTLK2BRD4MAPTHIF1A | |
| SCHEMBL6338486 | 0.86 | RET (0.43) | RETTLK2NTRK1BRD4 | |
| SCHEMBL6336804 | 0.86 | RET (0.48) | RETTLK2BRD4 | |
| SCHEMBL6337237 | 0.85 | RET (0.43) | RETTLK2NTRK1BRD4KMT2A | |
| SCHEMBL6329102 | 0.85 | RET (0.45) | RETTLK2BRD4 | |
| SCHEMBL6330735 | 0.85 | RET (0.44) | RETTLK2NTRK1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6794395-B1 | Substituted indolinones, their manufacture and their use as medicaments | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-09-21 | — | — | US | disclosed |