Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 16/20 | 0.50 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.50 |
| ▸ | PBK | Q96KB5 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6781828 | 1.00 | PARP1 (0.50) | PARP1PARP2PBK | |
| SCHEMBL6787330 | 1.00 | PARP1 (0.50) | PARP1PARP2PBK | |
| SCHEMBL6782076 | 0.91 | PARP1 (0.48) | PARP1PARP2PBK | |
| SCHEMBL6782456 | 0.91 | PARP1 (0.48) | PARP1PARP2PBK | |
| SCHEMBL6782527 | 0.91 | PARP1 (0.48) | PARP1PARP2PBK | |
| SCHEMBL6787534 | 0.88 | PARP1 (0.47) | PARP1PARP2 | |
| SCHEMBL6781297 | 0.85 | PARP1 (0.51) | PARP1PARP2PBK | |
| SCHEMBL6782102 | 0.85 | PARP1 (0.51) | PARP1PARP2PBK | |
| SCHEMBL6780862 | 0.85 | PARP1 (0.51) | PARP1PARP2PBK | |
| SCHEMBL6781561 | 0.84 | PARP1 (0.50) | PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6737421-B1 | 4-CARBOXYAMIDO SUBSTITUTED; NEURODEGENERATIVE DISEASES; NEURONAL DAMAGE | ABBOTT GMBH & CO. KG (DE) | 2004-05-18 | — | — | US | disclosed |