Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 9/20 | 0.55 |
| ▸ | PFKFB4 | Q16877 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | MMP8 | P22894 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6724818 | 0.90 | KMT2A (0.52) | PFKFB3PFKFB4MEN1KMT2AMAPT | |
| SCHEMBL7067510 | 0.90 | PFKFB3 (0.52) | PFKFB3PFKFB4MEN1KMT2AMAPT | |
| SCHEMBL6718575 | 0.90 | PFKFB3 (0.52) | PFKFB3PFKFB4MEN1KMT2AMAPT | |
| SCHEMBL6714757 | 0.90 | PFKFB3 (0.52) | PFKFB3PFKFB4MEN1KMT2AMAPT | |
| SCHEMBL6714952 | 0.88 | PFKFB3 (0.51) | PFKFB3PFKFB4MEN1KMT2AMAPT | |
| SCHEMBL6718211 | 0.83 | NPC1 (0.47) | PFKFB3PFKFB4MEN1KMT2ALMNA | |
| SCHEMBL6716609 | 0.80 | MEN1 (0.49) | PFKFB3PFKFB4MEN1KMT2AMAPT | |
| SCHEMBL6724890 | 0.80 | MEN1 (0.51) | PFKFB3PFKFB4MEN1KMT2AMAPT | |
| SCHEMBL6720396 | 0.79 | KMT2A (0.51) | PFKFB3MEN1KMT2AMAPTLMNA | |
| SCHEMBL6717937 | 0.78 | MEN1 (0.49) | PFKFB3MEN1KMT2AMAPTF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6818651-B2 | ANTIINFLAMMATORY, ANTIASTHMATIC, SKIN, AND AUTOIMMUNE DISORDERS; CROHN*S DISEASE, ULCERATIVE COLITIS, CONJUCTIVITIS, MULTIPLE SCLEROSIS, AND RHEUMATOID ARTHRITIS; CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ALTANA PHARMA AG (DE) | 2004-11-16 | — | — | US | disclosed |
| EP-1337515-A1 | (DIHYDRO)ISOQUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2003-08-27 | — | — | EP | disclosed |
| WO-2002040450-A1 | (DIHYDRO)ISOQUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | ALTANA PHARMA AG (DE) | 2002-05-23 | — | — | WO | disclosed |