Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | PPIA | P62937 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | CASP3 | P42574 | 2/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4419740 | 0.90 | EGFR (0.38) | KMT2AMEN1MAPTNPSR1EGFR | |
| SCHEMBL4419732 | 0.90 | EGFR (0.38) | KMT2AMEN1MAPTNPSR1EGFR | |
| Hydrochloric Acid SCHEMBL4432011 | 0.89 | EGFR (0.37) | AURKAKMT2AMEN1NPSR1EGFR | |
| Hydrochloric Acid SCHEMBL4432013 | 0.89 | EGFR (0.37) | AURKAKMT2AMEN1NPSR1EGFR | |
| SCHEMBL6771114 | 0.72 | EGFR (0.45) | AURKAKDRKDM4EEGFRALDH1A1 | |
| SCHEMBL6771123 | 0.72 | EGFR (0.45) | AURKAKDRKDM4EEGFRALDH1A1 | |
| SCHEMBL6781420 | 0.71 | EGFR (0.43) | AURKAEGFR | |
| SCHEMBL4417586 | 0.69 | IKBKB (0.46) | AURKAKMT2ARAB9AKDRMAPK1 | |
| SCHEMBL4417588 | 0.69 | IKBKB (0.46) | AURKAKMT2ARAB9AKDRMAPK1 | |
| SCHEMBL4431418 | 0.66 | STK17B (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806274-B1 | IMMUNOREGULATION OR IMMUNOSUPPRESSIVE AGENTS; TYROSINE KINASE INHIBITORS; PREVENTING ORGAN TRANSPLANT REJECTION; AUTOIMMUNE CONDITIONS; REDUCED SIDE EFFECTS | ASTRAZENECA UK LIMITED (GB) | 2004-10-19 | — | — | US | disclosed |