Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSF1 | Q00613 | 1/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 9/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6788964 | 0.92 | SYK (0.44) | HSF1SYKMAPTNOS1RET | |
| SCHEMBL6783321 | 0.86 | HSF1 (0.56) | HSF1MKNK1EGFRMAPTPOLB | |
| SCHEMBL6909983 | 0.85 | HSF1 (0.51) | HSF1MKNK1SYKEGFRMAPT | |
| SCHEMBL27595965 | 0.80 | HSF1 (0.50) | HSF1MKNK1SYKEGFRMAPT | |
| SCHEMBL18196438 | 0.80 | MKNK1 (0.53) | HSF1MKNK1SYKEGFRMAPT | |
| SCHEMBL6782806 | 0.78 | MAPT (0.46) | HSF1SYKMAPTNOS1RET | |
| SCHEMBL9985978 | 0.77 | HSF1 (0.47) | HSF1MKNK1ROCK2ROCK1 | |
| SCHEMBL27595864 | 0.77 | PIK3CA (0.47) | HSF1MAPTROCK2ROCK1MAPK1 | |
| SCHEMBL6787283 | 0.73 | HSF1 (0.72) | HSF1MKNK1SYKEGFRMAPT | |
| SCHEMBL27595866 | 0.72 | HSF1 (0.50) | HSF1MKNK1SYKEGFRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6743795-B1 | INHIBITORS FOR HEPATITIS B AND ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS) BECAUSE THEY INTERFERE WITH REMOVAL OF RNA STRAND FROM RNA-DNA HYBRID FORMED DURING THE REVERSE TRANSCRIPTION OF VIRAL RNA TO DNA | DONG WHA PHARM. IND. CO. LTD. (KR) | 2004-06-01 | — | — | US | disclosed |