Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 9/20 | 0.43 |
| ▸ | ESR1 | P03372 | 9/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 9/20 | 0.43 |
| ▸ | TOP1 | P11387 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6781964 | 1.00 | HRAS (0.43) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL6780838 | 0.99 | HRAS (0.42) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL6786934 | 0.93 | HDAC1 (0.42) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL6780499 | 0.91 | HRAS (0.43) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7118414 | 0.90 | HRAS (0.48) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7117804 | 0.90 | HRAS (0.48) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL6781278 | 0.86 | HDAC1 (0.47) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL6776858 | 0.86 | HDAC1 (0.47) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL3454590 | 0.86 | HRAS (0.50) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL6780841 | 0.86 | HRAS (0.50) | HRASESR1ESR2TOP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6753316-B1 | 3-ACRYLAMIDOPYRAZOLE-5-CARBOXAMIDE DERIVATIVES | PHARMACIA & UPJOHN S.P.A. (IT) | 2004-06-22 | — | — | US | disclosed |