Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 8/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.45 |
| ▸ | BUB1 | O43683 | 2/20 | 0.36 |
| ▸ | PADI4 | Q9UM07 | 5/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL677853 | 0.87 | AURKA (0.43) | AURKAAURKBBUB1ARCYP11B1 | |
| SCHEMBL679502 | 0.85 | AURKA (0.38) | AURKAAURKBBUB1PADI4AR | |
| SCHEMBL679211 | 0.82 | AURKA (0.40) | AURKAAURKBBUB1AR | |
| SCHEMBL679212 | 0.81 | AURKA (0.39) | AURKAAURKBBUB1AR | |
| SCHEMBL678780 | 0.78 | AURKA (0.72) | AURKAAURKB | |
| SCHEMBL678853 | 0.77 | GRM5 (0.31) | BUB1GRM5 | |
| SCHEMBL13553241 | 0.66 | AURKA (0.61) | AURKAAURKB | |
| SCHEMBL3454662 | 0.62 | AURKA (1.00) | AURKAAURKB | |
| SCHEMBL7695409 | 0.61 | PADI4 (0.36) | AURKAAURKBPADI4 | |
| SCHEMBL3464852 | 0.60 | AURKA (0.65) | AURKAAURKBAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110269758-A1 | NAPHTHYRIDINONES AS PROTEIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2011-11-03 | — | — | US | claimed |
| WO-2010002779-A2 | NAPHTHYRIDININONES AS AURORA KINASE INHIBITORS | MERCK SERONO S.A. (CH) | 2010-01-07 | — | — | WO | claimed |
| US-20110269758-A1 | NAPHTHYRIDINONES AS PROTEIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2011-11-03 | — | — | US | disclosed |
| WO-2010002779-A2 | NAPHTHYRIDININONES AS AURORA KINASE INHIBITORS | MERCK SERONO S.A. (CH) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269758-A1 | NAPHTHYRIDINONES AS PROTEIN KINASE INHIBITORS | AURKA, AURKC, AURKB | AURKA 1/4885AURKB 3/4885BUB1 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.